Phloroglucinols from Anti-Microbial Deposit-Resins of Australian Stingless Bees (Tetragonula carbonaria)

Carmelina F Massaro; Thomas J Smyth; W F Smyth; Tim Heard; Sara Leonhardt; Mohammad Katouli; Helen M Wallace; Peter R Brooks

doi:10.1002/ptr.5225

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Phloroglucinols from Anti-Microbial Deposit-Resins of Australian Stingless Bees (Tetragonula carbonaria)

Journal article

Peer reviewed

Phloroglucinols from Anti-Microbial Deposit-Resins of Australian Stingless Bees (Tetragonula carbonaria)

Carmelina F Massaro, Thomas J Smyth, W F Smyth, Tim Heard, Sara Leonhardt, Mohammad Katouli, Helen M Wallace and Peter R Brooks

Phytotherapy Research: an international journal devoted to medical and scientific research on plants and plant products, Vol.29(1), pp.48-58

2015

DOI: https://doi.org/10.1002/ptr.5225

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Abstract

propolis

flavonoids

Staphylococcus aureus

Myrtaceae

triketones

dereplication

Stingless bees accumulate deposits of plant resins that are mixed with beeswax to produce propolis. Previous studies have reported anti-microbial constituents of stingless bee (Tetragonula carbonaria) propolis from East Australia, but several components remained to be characterized. In the search of natural products yet unreported for Australian propolis, four bee deposit-resins of T. carbonaria bees were analysed by gas and liquid chromatography mass spectrometry with accurate mass measurements. Ethanolic extracts of the deposit-resins were tested in vitro against Staphylococcus aureus ATCC 25983 and Pseudomonas aeruginosa ATCC 27853 by the agar diffusion method. Phloroglucinols, flavonoids and isoprenoids were identified in samples. The crude extracts showed strong anti-staphylococcal effects but were less active against the Gram-negative bacterium. The diagnostic data enabled the identification of markers that can be used for profiling other Australian propolis sources and to target the isolation of bioactive phloroglucinols in future studies against antibiotic resistant S. aureus strains. Copyright © 2014 John Wiley & Sons, Ltd.

Details

Title: Phloroglucinols from Anti-Microbial Deposit-Resins of Australian Stingless Bees (Tetragonula carbonaria)
Authors: Carmelina F Massaro (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Thomas J Smyth (Author) - Teagasc Food Research Center, United Kingdom
W F Smyth (Author) - University of Ulster, United Kingdom
Tim Heard (Author) - CSIRO Brisbane
Sara Leonhardt (Author) - University of Würzburg
Mohammad Katouli (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Helen M Wallace (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Peter R Brooks (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Publication details: Phytotherapy Research: an international journal devoted to medical and scientific research on plants and plant products, Vol.29(1), pp.48-58
Publisher: John Wiley & Sons Ltd.
Date published: 2015
DOI: 10.1002/ptr.5225
ISSN: 0951-418X
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; GeneCology Research Centre - Legacy; School of Health and Sport Sciences - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99448627802621
Output Type: Journal article

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Web Of Science research areas: Chemistry, Medicinal; Pharmacology & Pharmacy

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