Phenotypical Characterisation of the Isolated Norfolk Island Population Focusing on Epidemiological Indicators of Cardiovascular Disease

C Bellis; Roger Hughes; K N Begley; S Quinlan; R A Lea; S C Heath; J Blangero; L R Griffiths

doi:10.1159/000090545

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Phenotypical Characterisation of the Isolated Norfolk Island Population Focusing on Epidemiological Indicators of Cardiovascular Disease

Journal article

Peer reviewed

Phenotypical Characterisation of the Isolated Norfolk Island Population Focusing on Epidemiological Indicators of Cardiovascular Disease

C Bellis, Roger Hughes, K N Begley, S Quinlan, R A Lea, S C Heath, J Blangero and L R Griffiths

Human Heredity: international journal of human and medical genetics, Vol.60(4), pp.211-219

2005

DOI: https://doi.org/10.1159/000090545

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Abstract

Genetics

isolated population

cardiovascular disease

linkage disequilibrium

quantitative trait loci

Norfolk Island

Objectives: Only 193 people from Pitcairn Island, all descended from 9 'Bounty' mutineers and 12 Tahitian women, moved to the uninhabited Norfolk Island in 1856. Our objective was to assess the population of Norfolk Island, several thousand km off the eastern coast of Australia, as a genetic isolate of potential use for cardiovascular disease (CVD) gene mapping. Methods: A total of 602 participants, approximately two thirds of the island's present adult population, were characterized for a panel of CVD risk factors. Statistical power and heritability were calculated. Results: Norfolk Islander's possess an increased prevalence of hypertension, obesity and multiple CVD risk factors when compared to outbred Caucasian populations. 64% of the study participants were descendents of the island's original founder population. Triglycerides, cholesterol, and blood pressures all had heritabilities above 0.2. Conclusions: The Norfolk Island population is a potentially useful genetic isolate for gene mapping studies aimed at identifying CVD risk factor quantitative trait loci (QTL).

Details

Title: Phenotypical Characterisation of the Isolated Norfolk Island Population Focusing on Epidemiological Indicators of Cardiovascular Disease
Authors: C Bellis (Author) - Griffith University
Roger Hughes (Author) - University of the Sunshine Coast - Faculty of Science, Health and Education
K N Begley (Author) - Griffith University
S Quinlan (Author) - Griffith University
R A Lea (Author) - Griffith University
S C Heath (Author) - Centre National de Genotypage
J Blangero (Author) - Southwest Foundation for Biomedical Research
L R Griffiths (Author) - Griffith University
Publication details: Human Heredity: international journal of human and medical genetics, Vol.60(4), pp.211-219
Publisher: S. Karger AG
Date published: 2005
DOI: 10.1159/000090545
ISSN: 0001-5652
Organisation Unit: University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99449556102621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Genetics & Heredity

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