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Published VersionCC BY V4.0, Open Access
Journal article
Phase–Amplitude Coupling, Mental Health and Cognition: Implications for Adolescence
Frontiers in Human Neuroscience, Vol.15, pp.1-7
2021
Appears in Thompson Institute Research Collection
Abstract
Identifying biomarkers of developing mental disorder is crucial to improving early identification and treatment—a key strategy for reducing the burden of mental disorders. Cross-frequency coupling between two different frequencies of neural oscillations is one such promising measure, believed to reflect synchronization between local and global networks in the brain. Specifically, in adults phase–amplitude coupling (PAC) has been shown to be involved in a range of cognitive processes, including working and long-term memory, attention, language, and fluid intelligence. Evidence suggests that increased PAC mediates both temporary and lasting improvements in working memory elicited by transcranial direct-current stimulation and reductions in depressive symptoms after transcranial magnetic stimulation. Moreover, research has shown that abnormal patterns of PAC are associated with depression and schizophrenia in adults. PAC is believed to be closely related to cortico-cortico white matter (WM) microstructure, which is well established in the literature as a structural mechanism underlying mental health. Some cognitive findings have been replicated in adolescents and abnormal patterns of PAC have also been linked to ADHD in young people. However, currently most research has focused on cross-sectional adult samples. Whereas initial hypotheses suggested that PAC was a state-based measure due to an early focus on cognitive, task-based research, current evidence suggests that PAC has both state-based and stable components. Future longitudinal research focusing on PAC throughout adolescent development could further our understanding of the relationship between mental health and cognition and facilitate the development of new methods for the identification and treatment of youth mental health.
Details
- Title
- Phase–Amplitude Coupling, Mental Health and Cognition: Implications for Adolescence
- Authors
- Dashiell Sacks (Corresponding Author) - University of the Sunshine Coast, Queensland, Thompson InstitutePaul Schwenn (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteLarisa McLoughlin (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteJim Lagopoulos (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteDaniel Hermens (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
- Publication details
- Frontiers in Human Neuroscience, Vol.15, pp.1-7
- Publisher
- Frontiers Research Foundation
- Date published
- 2021
- DOI
- 10.3389/fnhum.2021.622313
- ISSN
- 1662-5161
- Copyright note
- Copyright © 2021 Sacks, Schwenn, McLoughlin, Lagopoulos and Hermens. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Organisation Unit
- University of the Sunshine Coast, Queensland; Thompson Institute
- Language
- English
- Record Identifier
- 99521807202621
- Output Type
- Journal article
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- Web Of Science research areas
- Neurosciences
- Psychology