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Journal article
Pharmacokinetic and pharmacodynamic considerations for treating sarcoptic mange with cross-relevance to Australian wildlife
International Journal for Parasitology: Drugs and Drug Resistance, Vol.21, pp.97-113
2023
Abstract
Sarcoptes scabiei is the microscopic burrowing mite responsible for sarcoptic mange, which is reported in approximately 150 mammalian species. In Australia, sarcoptic mange affects a number of native and introduced wildlife species, is particularly severe in bare nosed wombats (Vombatus ursinus) and an emerging issue in koala and quenda. There are a variety of acaricides available for the treatment of sarcoptic mange which are generally effective in eliminating mites from humans and animals in captivity. In wild populations, effective treatment is challenging, and concerns exist regarding safety, efficacy and the potential emergence of acaricide resistance. There are risks where acaricides are used intensively or inadequately, which could adversely affect treatment success rates as well as animal welfare. While reviews on epidemiology, treatment strategies, and pathogenesis of sarcoptic mange in wildlife are available, there is currently no review evaluating the use of specific acaricides in the context of their pharmacokinetic and pharmacodynamic properties, and subsequent likelihood of emerging drug resistance, particularly for Australian wildlife. This review critically evaluates acaricides that have been utilised to treat sarcoptic mange in wildlife, including dosage forms and routes, pharmacokinetics, mode of action and efficacy. We also highlight the reports of resistance of S. scabiei to acaricides, including clinical and in vitro observations.
Details
- Title
- Pharmacokinetic and pharmacodynamic considerations for treating sarcoptic mange with cross-relevance to Australian wildlife
- Authors
- Kotaro Takano (Author) - University of the Sunshine Coast, Queensland, School of Science, Technology and EngineeringLachlan De Hayr (Author) - University of the Sunshine Coast, Queensland, School of Health - BiomedicineScott Carver (Author) - University of TasmaniaRobert Harvey (Author) - University of the Sunshine Coast, Queensland, School of HealthKate Mounsey (Corresponding Author) - University of the Sunshine Coast, Queensland, School of Health - Biomedicine
- Publication details
- International Journal for Parasitology: Drugs and Drug Resistance, Vol.21, pp.97-113
- Publisher
- Elsevier Ltd
- Date published
- 2023
- DOI
- 10.1016/j.ijpddr.2023.02.004
- ISSN
- 2211-3207
- Organisation Unit
- School of Health - Biomedicine; School of Health; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99710098702621
- Output Type
- Journal article
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- Pharmacology & Pharmacy
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