Pharmacokinetic and pharmacodynamic considerations for treating sarcoptic mange with cross-relevance to Australian wildlife

Kotaro Takano; Lachlan De Hayr; Scott Carver; Robert Harvey; Kate Mounsey

doi:10.1016/j.ijpddr.2023.02.004

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Pharmacokinetic and pharmacodynamic considerations for treating sarcoptic mange with cross-relevance to Australian wildlife

Journal article

Open access

Peer reviewed

Pharmacokinetic and pharmacodynamic considerations for treating sarcoptic mange with cross-relevance to Australian wildlife

Kotaro Takano, Lachlan De Hayr, Scott Carver, Robert Harvey and Kate Mounsey

International Journal for Parasitology: Drugs and Drug Resistance, Vol.21, pp.97-113

2023

DOI: https://doi.org/10.1016/j.ijpddr.2023.02.004

PMCID: PMC10023865

PMID: 36906936

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Abstract

Sarcoptes scabiei

Sarcoptic mange

Scabies

Treatment

Moxidectin

Ivermectin

Fluralaner

Drug resistance

Ligand-gated ion channels

Sarcoptes scabiei is the microscopic burrowing mite responsible for sarcoptic mange, which is reported in approximately 150 mammalian species. In Australia, sarcoptic mange affects a number of native and introduced wildlife species, is particularly severe in bare nosed wombats (Vombatus ursinus) and an emerging issue in koala and quenda. There are a variety of acaricides available for the treatment of sarcoptic mange which are generally effective in eliminating mites from humans and animals in captivity. In wild populations, effective treatment is challenging, and concerns exist regarding safety, efficacy and the potential emergence of acaricide resistance. There are risks where acaricides are used intensively or inadequately, which could adversely affect treatment success rates as well as animal welfare. While reviews on epidemiology, treatment strategies, and pathogenesis of sarcoptic mange in wildlife are available, there is currently no review evaluating the use of specific acaricides in the context of their pharmacokinetic and pharmacodynamic properties, and subsequent likelihood of emerging drug resistance, particularly for Australian wildlife. This review critically evaluates acaricides that have been utilised to treat sarcoptic mange in wildlife, including dosage forms and routes, pharmacokinetics, mode of action and efficacy. We also highlight the reports of resistance of S. scabiei to acaricides, including clinical and in vitro observations.

Details

Title: Pharmacokinetic and pharmacodynamic considerations for treating sarcoptic mange with cross-relevance to Australian wildlife
Authors: Kotaro Takano (Author) - University of the Sunshine Coast, Queensland, School of Science, Technology and Engineering
Lachlan De Hayr (Author) - University of the Sunshine Coast, Queensland, School of Health - Biomedicine
Scott Carver (Author) - University of Tasmania
Robert Harvey (Author) - University of the Sunshine Coast, Queensland, School of Health
Kate Mounsey (Corresponding Author) - University of the Sunshine Coast, Queensland, School of Health - Biomedicine
Publication details: International Journal for Parasitology: Drugs and Drug Resistance, Vol.21, pp.97-113
Publisher: Elsevier Ltd
Date published: 2023
DOI: 10.1016/j.ijpddr.2023.02.004
ISSN: 2211-3207
PMID: 36906936; PMC10023865
Grants: Developing treatment for feasible control of mange disease in wombat populations, LP180101251, Australian Research Council (Australia, Canberra) - ARC
Organisation Unit: School of Health - Biomedicine; School of Health; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99710098702621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Parasitology; Pharmacology & Pharmacy

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