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Pharmacoeconomic evaluation of original and generic temozolomide capsules in the treatment of glioma654.49 kB
Published VersionCC BY V4.0, Open Access
Journal article
Pharmacoeconomic evaluation of original and generic temozolomide capsules in the treatment of glioma
Intelligent Pharmacy, Vol.1(1), pp.26-31
2023
Abstract
Aim
Original patented drugs and generic drugs using the same pharmaceutical ingredients may have different clinical efficacies and prices. This study was designed to compare the clinical efficacy and cost-effectiveness of original imported temozolomide capsules and those generic capsules manufactured domestically, with a pharmacoeconomic evaluation being performed.
Methods
In this retrospective study, 103 glioma patients from 2008 to 2018 were divided into the generic temozolomide group (72 cases) and the imported temozolomide group (31 cases). The 2-year overall survival (OS) and disease progression free survival (PFS) of the two groups were analyzed using Kaplan Meier survival curves, and the 2-year disease control rate and 2-year survival rate were calculated. The incidence of adverse reactions was also compared between the two groups. A pharmacoeconomic evaluation was performed on the two groups according to the total cost of treatment per capita.
Results
The 2-year disease control rate of the domestic drug group was 52.8% and the imported drug group was 67.7%. The 2-year survival rate of the domestic drug group was 68.10%, with the imported drug group being 74.20%. The total cost of treatment per patient/2-year PFS time in the domestic drug group was 7000.55 yuan/month; while the imported drug group was 7705.41 yuan/month. The total cost of treatment per patient/2-year OS time in domestic drug group was 5821.20 yuan/month, while the imported drug group was 7035.53 yuan/month.
Conclusion
There was no significant difference between the domestic drug group and the imported drug group in treatment efficacy and the total cost/2-year PFS time of the two groups were not significantly different. However, the total cost/2-year OS time of the domestic group was significant lower than the imported group, revealing a certain cost-effective advantage.
Details
- Title
- Pharmacoeconomic evaluation of original and generic temozolomide capsules in the treatment of glioma
- Authors
- Ming Gu - Huazhong University of Science and TechnologyChangdong Diao - Huazhong University of Science and TechnologyMitchell A Sullivan - The University of QueenslandHaixia Zhu - Huazhong University of Science and TechnologyQi Yuan - Huazhong University of Science and TechnologyJinmei Liu - Huazhong University of Science and TechnologyShijun Li - Huazhong University of Science and TechnologyYu Zhang - Huazhong University of Science and TechnologyBin Deng (Corresponding Author) - Huazhong University of Science and TechnologyChen Shi (Corresponding Author) - Huazhong University of Science and Technology
- Publication details
- Intelligent Pharmacy, Vol.1(1), pp.26-31
- Publisher
- KeAi Publishing Communications Ltd.
- Date published
- 2023
- DOI
- 10.1016/j.ipha.2023.04.006
- ISSN
- 2949-866X
- Copyright note
- © 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Data Availability
- After publication, we can provide the data to others with the permission of the corresponding author. A proposal with detailed description of study objectives and statistical analysis plan will be needed for evaluation of the reasonability of requests. The corresponding authors have the right to decide whether to share the data or not based on the research objectives and plan provided.
- Grant note
- This work was supported by the National Key Research and Development Plan of China (2017YFC0909900) and the Hubei Provincial Natural Science Foundation of China (2022CFB092).
- Organisation Unit
- School of Health - Biomedicine
- Language
- English
- Record Identifier
- 991035093202621
- Output Type
- Journal article
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