Phage 3396 from a Streptococcus dysgalactiae subsp. equisimilis Pathovar May Have Its Origins in Streptococcus pyogenes

M R Davies; David J McMillan; G H Van Domselaar; M K Jones; K S Sriprakash

doi:10.1128/JB.01590-06

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Phage 3396 from a Streptococcus dysgalactiae subsp. equisimilis Pathovar May Have Its Origins in Streptococcus pyogenes

Journal article

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Peer reviewed

Phage 3396 from a Streptococcus dysgalactiae subsp. equisimilis Pathovar May Have Its Origins in Streptococcus pyogenes

M R Davies, David J McMillan, G H Van Domselaar, M K Jones and K S Sriprakash

Journal of Bacteriology, Vol.189(7), pp.2646-2652

2007

DOI: https://doi.org/10.1128/JB.01590-06

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Abstract

Biological Sciences

Medical and Health Sciences

Agricultural and Veterinary Sciences

Streptococcus dysgalactiae subsp. equisimilis strains (group G streptococcus [GGS]) are largely defined as commensal organisms, which are closely related to the well-defined human pathogen, the group A streptococcus (GAS). While lateral gene transfers are emerging as a common theme in these species, little is known about the mechanisms and role of these transfers and their effect on the population structure of streptococci in nature. It is now becoming evident that bacteriophages are major contributors to the genotypic diversity of GAS and, consequently, are pivotal to the GAS strain structure. Furthermore, bacteriophages are strongly associated with altering the pathogenic potential of GAS. In contrast, little is know about phages from GGS and their role in the population dynamics of GGS. In this study we report the first complete genome sequence of a GGS phage, Φ3396. Exhibiting high homology to the GAS phage Φ315.1, the chimeric nature of Φ3396 is unraveled to reveal evidence of extensive ongoing genetic diversity and dissemination of streptococcal phages in nature. Furthermore, we expand on our recent findings to identify inducible Φ3396 homologues in GAS from a region of endemicity for GAS and GGS infection. Together, these findings provide new insights into not only the population structure of GGS but also the overall population structure of the streptococcal genus and the emergence of pathogenic variants.

Details

Title: Phage 3396 from a Streptococcus dysgalactiae subsp. equisimilis Pathovar May Have Its Origins in Streptococcus pyogenes
Authors: M R Davies (Author) - Queensland Institute of Medical Research
David J McMillan (Author) - Queensland Institute of Medical Research
G H Van Domselaar (Author) - University of Manitoba, Canada
M K Jones (Author) - Queensland Institute of Medical Research
K S Sriprakash (Author) - Queensland Institute of Medical Research
Publication details: Journal of Bacteriology, Vol.189(7), pp.2646-2652
Publisher: American Society for Microbiology
Date published: 2007
DOI: 10.1128/JB.01590-06
ISSN: 0021-9193
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99450113402621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Microbiology

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