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Persistent chlamydial infections: role in inflammation and challenges for vaccine development
Journal article   Open access

Persistent chlamydial infections: role in inflammation and challenges for vaccine development

Louise M Hafner and Peter Timms
Mucosal Immunology Update, Vol.13(4), pp.4-7
2005
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Abstract

Medical Microbiology chlamydia persistence vaccine development
The development of chlamydial vaccines continues to be a major challenge for researchers. While acute infections are the main target of vaccine development groups, Chlamydia is well known for its ability to establish chronic or persistent infections in its host. To date, little effort has focussed specifically on the challenges of vaccines to successfully combat the chronic or persistent phase of the disease and yet this will be a necessary aspect of any fully successful chlamydial vaccine. This short review specifically examines the phenomenon of chlamydial persistence and the unique challenges that this brings to vaccine development.

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