Journal article
Persistence of Multiple Antibiotic Resistant Strains of Acinetobacter baumannii Carrying Class 1 Integron in a Hospital Setting
Microbial Drug Resistance: mechanism, epidemiology, and disease, Vol.15(3), pp.167-172
2009
Abstract
Forty-nine strains of multiresistant Aceinetobacter baumannii isolated from intensive care unit patients in Royal Brisbane and Women Hospital (RBWH) between 2001 and 2003 and four epidemiologically unrelated strains from three other hospitals were tested (n=53) for their genetic relatedness using pulsed-field gel electrophoresis (PFGE) and for the presence of different classes of integrons. With PFGE, these strains were divided into three common (C) but closely related types (i.e., C1, C1a, and C1b) and eight single (S) types (S1-S8). C1 contained 40 isolates, while C1a and C1b contained 5 and 2 isolates, respectively. All isolates from Royal Brisbane and Women Hospital (RBWH) were resistant to 12 or more antibiotics. Four common pattern of antibiotic resistance (PAR) was observed among the isolates. The dominant PAR contained 39 strains from RBWH, isolated during 2000 (n=6), 2001 (n=16), and 2002 (n=17) and were resistant to 14 antibiotics. Of these, 36 strains (92%) had identical PAR/PFGE types. Class 1 integrase genes were detected in all of the 53 isolates with 5 isolates also having class 2 integrase gene. No class 3 integrase gene was detected among the isolates. Our data suggest the presence of a dominant and persistent clone of multiresistant A. baumannii strain carrying class 1 integron in this hospital setting.
Details
- Title
- Persistence of Multiple Antibiotic Resistant Strains of Acinetobacter baumannii Carrying Class 1 Integron in a Hospital Setting
- Authors
- Ysanne B Long (Author) - University of the Sunshine Coast - Faculty of Science, Health and EducationJ Faoagali (Author) - Royal Brisbane and Women HospitalJ Bodman (Author) - Royal Brisbane and Women HospitalN George (Author) - Royal Brisbane and Women HospitalDavid B McKay (Author) - University of the Sunshine Coast - Faculty of Science, Health and EducationMohammad Katouli (Author) - University of the Sunshine Coast - Faculty of Science, Health and Education
- Publication details
- Microbial Drug Resistance: mechanism, epidemiology, and disease, Vol.15(3), pp.167-172
- Publisher
- Mary Ann Liebert, Inc. Publishers
- Date published
- 2009
- DOI
- 10.1089/mdr.2009.0884
- ISSN
- 1076-6294
- Copyright note
- Copyright © 2009 Mary Ann Liebert, Inc.; Microbial Drug Resistance is available online at: http://online.liebertpub.com . This is a copy of an article published in the Microbial Drug Resistance.
- Organisation Unit
- School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99449455802621
- Output Type
- Journal article
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