Peripheral modulation of the endocannabinoid system in metabolic disease

Nirajan Shrestha; James S. M. Cuffe; Dana S. Hutchinson; John P. Headrick; Anthony V. Perkins; Andrew J. McAinch; Deanne H. Hryciw

doi:10.1016/j.drudis.2018.01.029

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Peripheral modulation of the endocannabinoid system in metabolic disease

Journal article

Peer reviewed

Peripheral modulation of the endocannabinoid system in metabolic disease

Nirajan Shrestha, James S. M. Cuffe, Dana S. Hutchinson, John P. Headrick, Anthony V. Perkins, Andrew J. McAinch and Deanne H. Hryciw

Drug Discovery Today, Vol.23(3), pp.592-604

2018

DOI: https://doi.org/10.1016/j.drudis.2018.01.029

PMID: 29331500

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Abstract

Dysfunction of the endocannabinoid system (ECS) has been identified in metabolic disease. Cannabinoid receptor 1 (CB1) is abundantly expressed in the brain but also expressed in the periphery. Cannabinoid receptor 2 (CB2) is more abundant in the periphery, including the immune cells. In obesity, global antagonism of overexpressed CB1 reduces bodyweight but leads to centrally mediated adverse psychological outcomes. Emerging research in isolated cultured cells or tissues has demonstrated that targeting the endocannabinoid system in the periphery alleviates the pathologies associated with metabolic disease. Further, peripheral specific cannabinoid ligands can reverse aspects of the metabolic phenotype. This Keynote review will focus on current research on the functionality of peripheral modulation of the ECS for the treatment of obesity.

Details

Title: Peripheral modulation of the endocannabinoid system in metabolic disease
Authors: Nirajan Shrestha (Author) - Griffith University
James S. M. Cuffe (Author) - Griffith University
Dana S. Hutchinson (Author) - Monash University
John P. Headrick (Author) - Griffith University
Anthony V. Perkins (Author) - Griffith University
Andrew J. McAinch (Author) - Victoria University
Deanne H. Hryciw (Corresponding Author) - Victoria University
Publication details: Drug Discovery Today, Vol.23(3), pp.592-604
Publisher: Elsevier Ltd, Trends Journals
DOI: 10.1016/j.drudis.2018.01.029
ISSN: 1878-5832
PMID: 29331500
Grant note: Griffith University Postgraduate Research fellowship (GUPF) Griffith University International Postgraduate Research Scholarship (GUIPRS) Allen Foundation (USA) Griffith Health Top Up Scholarship
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy; School of Health
Language: English
Record Identifier: 99685293302621
Output Type: Journal article

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