Pedican: an online gene resource for pediatric cancers with literature evidence

Min Zhao; Lei Ma; Yining Liu; Hong Qu

doi:10.1038/srep11435

Back

Pedican: an online gene resource for pediatric cancers with literature evidence

Journal article

Open access

Peer reviewed

Pedican: an online gene resource for pediatric cancers with literature evidence

Min Zhao, Lei Ma, Yining Liu and Hong Qu

Scientific Reports, Vol.5, 11435

2015

DOI: https://doi.org/10.1038/srep11435

Files and links (2)

pdf

PDF - Published Version (Open Access)2.46 MBDownload View

Published VersionPDF - Published Version (Open Access)CC BY V4.0, Open Access

url

https://doi.org/10.1038/srep11435View

Published Version

Abstract

Biochemistry and Cell Biology

Other Physical Sciences

Pediatric cancer (PC), that is cancer occurring in children, is the leading cause of death among children worldwide, with an incidence of 175,000 per year. Elucidating the genetic abnormalities and underlying cellular mechanisms may provide less toxic curative treatments. Therefore, it is important to understand the pathology of pediatric cancer at the genetic, genomic and epigenetic level. To unveil the cellular complexity of PC, we have developed a database of pediatric cancers (Pedican), the first literature-based pediatric gene data resource by comprehensive literature curation and data integration. In the current release, Pedican contains 735 human genes, 88 gene fusion and 24 chromosome abnormal events curated from 2245 PubMed abstracts. Pedican provides detailed annotations for each gene, such as Entrez gene information, involved pathways, protein-protein interactions, mutations, gene expression, methylation sites, TF regulation, and post-translational modification. Additionally Pedican has a user-friendly web interface, which allows sophisticated text query, sequence searches, and browsing by highlighted literature evidence and hundreds of cancer types. Overall, our curated pediatric cancer-related gene list maps the genomic and cellular landscape for various pediatric cancers, providing a valuable resource for further experiment design. The Pedican is available at http://pedican.bioinfo-minzhao.org/.

Details

Title: Pedican: an online gene resource for pediatric cancers with literature evidence
Authors: Min Zhao (Author) - Peking University, China
Lei Ma (Author) - Peking University, China
Yining Liu (Author) - Peking University, China
Hong Qu (Author) - Peking University, China
Publication details: Scientific Reports, Vol.5, 11435; 11
Publisher: Nature Publishing Group
Date published: 2015
DOI: 10.1038/srep11435
ISSN: 2045-2322
Copyright note: Copyright © 2015 The Authors. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; GeneCology Research Centre - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99451053602621
Output Type: Journal article

Metrics

27 File views/ downloads

335 Record Views

6 Times Cited - Web of Science

See more details

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Web Of Science research areas: Biochemistry & Molecular Biology

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites