Journal article
Patterns of transitional mutation biases within and among mammalian genomes
Molecular Biology and Evolution, Vol.20(6), pp.988-993
2003
Abstract
Significant transition/transversion mutation bias is a well-appreciated aspect of mammalian nuclear genomes; however, patterns of bias among genes within a genome and among species remain largely uncharacterized. Understanding these patterns is important for understanding similarities and differences in mutational patterns among genomes and genomic regions. Therefore, we have conducted an analysis of 7,587 pairs of sequences of 4,347 mammalian protein-coding genes from seven species (human, mouse, rat, cow, sheep, pig, and macaque) and from the introns of 51 gene pairs and multiple intergenic regions (37 kbp, 52 kbp and 65 kbp) from the human, chimpanzee, and baboon genomes. Our analyses show that genes and regions with widely varying base composition exhibit uniformity of transition mutation rate both within and among mammalian lineages, as long as the transitional mutations caused by CpG hypermutability are excluded. The estimates show no relationship to potential intrachromosomal or interchromosomal effects. This uniformity points to similarity in point mutation processes in genomic regions with substantially different GC-content biases.
Details
- Title
- Patterns of transitional mutation biases within and among mammalian genomes
- Authors
- M S Rosenberg (Author) - Arizona State University, United StatesSankar Subramanian (Author) - Arizona State University, United StatesS Kumar (Author) - Arizona State University, United States
- Publication details
- Molecular Biology and Evolution, Vol.20(6), pp.988-993
- Publisher
- Oxford University Press
- Date published
- 2003
- DOI
- 10.1093/molbev/msg113
- ISSN
- 0737-4038
- Organisation Unit
- School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99450929102621
- Output Type
- Journal article
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