Pathophysiology of Sepsis-Related Cardiac Dysfunction: Driven by Inflammation, Energy Mismanagement, or Both?

K Drosatos; A Lymperopoulos; P J Kennel; Nina M Pollak; P C Schulze; I J Goldberg

doi:10.1007/s11897-014-0247-z

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Pathophysiology of Sepsis-Related Cardiac Dysfunction: Driven by Inflammation, Energy Mismanagement, or Both?

Journal article

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Pathophysiology of Sepsis-Related Cardiac Dysfunction: Driven by Inflammation, Energy Mismanagement, or Both?

K Drosatos, A Lymperopoulos, P J Kennel, Nina M Pollak, P C Schulze and I J Goldberg

Current Heart Failure Reports, Vol.12(2), pp.130-140

2015

DOI: https://doi.org/10.1007/s11897-014-0247-z

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Abstract

Sepsis is a systemic inflammatory response that follows bacterial infection. Cardiac dysfunction is an important consequence of sepsis that affects mortality and has been attributed to either elevated inflammation or suppression of both fatty acid and glucose oxidation and eventual ATP depletion. Moreover, cardiac adrenergic signaling is compromised in septic patients and this aggravates further heart function. While anti-inflammatory therapies are important for the treatment of the disease, administration of anti-inflammatory drugs did not improve survival in septic patients. This review article summarizes findings on inflammatory and other mechanisms that are triggered in sepsis and affect cardiac function and mortality. Particularly, it focuses on the effects of the disease in metabolic pathways, as well as in adrenergic signaling and the potential interplay of the latter with inflammation. It is suggested that therapeutic approaches should include combination of anti-inflammatory treatments, stimulation of energy production, and restoration of adrenergic signaling in the heart. © 2014, Springer Science+Business Media New York.

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Title: Pathophysiology of Sepsis-Related Cardiac Dysfunction: Driven by Inflammation, Energy Mismanagement, or Both?
Authors: K Drosatos (Author) - Temple University School of Medicine, United States
A Lymperopoulos (Author) - Nova Southeastern University College of Pharmacy, United States
P J Kennel (Author) - Columbia University College of Physicians and Surgeons, United States
Nina M Pollak (Author) - University of Graz, Austria
P C Schulze (Author) - Columbia University College of Physicians and Surgeons, United States
I J Goldberg (Author) - NYU-Langone School of Medicine, United States
Publication details: Current Heart Failure Reports, Vol.12(2), pp.130-140
Publisher: Springer Healthcare
Date published: 2015
DOI: 10.1007/s11897-014-0247-z
ISSN: 1546-9549
Copyright note: Copyright © 2015 The Author. This is a post-peer-review, pre-copyedit version of an article published in Current Heart Failure Reports. The final authenticated version is available online at: http://dx.doi.org/10.1007/s11897-014-0247-z
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99450326602621
Output Type: Journal article

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