Paris MEM: a study protocol for an effectiveness and efficiency trial on the treatment of traumatic stress in France after the 2015–16 terrorist attacks

A. Brunet; A. Ayrolles; L. Gambotti; R. Maatoug; C. Estellat; M. Descamps; N. Girault; K. Kalalou; G. Abgrall; F. Ducrocq; G. Vaiva; N. Jaafari; M. O. Krebs; E. Castaigne; I. Hanafy; M. Benoit; S. Mouchabac; I. Durand-Zaleski; M. C. Cabié; B. Millet; O. Guillin; F. Hodeib

doi:10.1186/s12888-019-2283-4

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Paris MEM: a study protocol for an effectiveness and efficiency trial on the treatment of traumatic stress in France after the 2015–16 terrorist attacks

Journal article

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Paris MEM: a study protocol for an effectiveness and efficiency trial on the treatment of traumatic stress in France after the 2015–16 terrorist attacks

A. Brunet, A. Ayrolles, L. Gambotti, R. Maatoug, C. Estellat, M. Descamps, N. Girault, K. Kalalou, G. Abgrall, F. Ducrocq, …

BMC Psychiatry, Vol.19, pp.1-9

2019

DOI: https://doi.org/10.1186/s12888-019-2283-4

PMID: 31703570

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Abstract

Post-traumatic stress disorder (PTSD)

Terrorism

Reconsolidation

Cost-effectiveness trial

Background: The Paris and Nice terrorist attacks affected a thousand of trauma victims and first-line responders. Because there were concerns that this might represent the first of several attacks, there was a need to quickly enhance the local capacities to treat a large number of individuals suffering from trauma-related disorders. Since Reconsolidation Therapy (RT) is brief, relatively easy to learn, well tolerated and effective, it appeared as the ideal first-line treatment to teach to clinicians in this context. Methods: This study protocol is a two-arm non-randomized, multicenter controlled trial, comparing RT to treatment as usual for the treatment of trauma-related disorders. RT consists of actively recalling one’s traumatic event under the influence of the ß-blocker propranolol, once a week, for 10–25 min with a therapist, over 6 consecutive weeks. This protocol evaluates the feasibility, effectiveness, and cost-utility of implementing RT as part of a large multi-center (N = 400) pragmatic trial with a one-year follow-up. Discussion: Paris MEM is the largest trial to date assessing the efficiency of RT in the aftermath of a large-scale man-made disaster. RT could possibly reinforce the therapeutic arsenal for the treatment of patients suffering from trauma-related disorders, not only for communities in western countries but also worldwide for terror- or disaster stricken communities.

Details

Title: Paris MEM: a study protocol for an effectiveness and efficiency trial on the treatment of traumatic stress in France after the 2015–16 terrorist attacks
Authors: A. Brunet - Boulevard de l'Hôpital
A. Ayrolles - Boulevard de l'Hôpital
L. Gambotti - Assistance Publique – Hôpitaux de Paris
R. Maatoug - Boulevard de l'Hôpital
C. Estellat - Assistance Publique – Hôpitaux de Paris
M. Descamps - Boulevard de l'Hôpital
N. Girault - Boulevard de l'Hôpital
K. Kalalou - Hôpital de Ville-Évrard
G. Abgrall - Hôtel-Dieu de Paris
F. Ducrocq - Centre Hospitalier Universitaire de Lille
G. Vaiva - Centre Hospitalier Universitaire de Lille
N. Jaafari - Centre Hospitalier Henri Laborit
M. O. Krebs - Centre Hospitalier Sainte-Anne
E. Castaigne - Bicêtre Hospital
I. Hanafy - Association Clinique et Thérapeutique Infantile du Val de Marne
M. Benoit - Hôpital Pasteur
S. Mouchabac - Assistance Publique – Hôpitaux de Paris
I. Durand-Zaleski - Evaluation et recherche en services et politiques en santé pour les populations vulnérables
M. C. Cabié - Hôpitaux de Saint Maurice
B. Millet (Corresponding Author) - Assistance Publique – Hôpitaux de Paris
O. Guillin - Centre Hospitalier du Rouvray
F. Hodeib - Sorbonne Université
Publication details: BMC Psychiatry, Vol.19, pp.1-9
Publisher: BioMed Central Ltd.
Date published: 2019
DOI: 10.1186/s12888-019-2283-4
ISSN: 1471-244X
PMID: 31703570
Copyright note: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Data Availability: The datasets used and/or analyzed during the current study belong to the AP-HP (Assistance Publique - Hopitaux de Paris) research directorate and will be available by request to the corresponding author.
Grant note: The study has been funded by Assistance Publique – Hôpitaux de Paris, Fondation Assistance Publique – Hopitaux de Paris and MSD Avenir.
Organisation Unit: Thompson Institute
Language: English
Record Identifier: 991105738602621
Output Type: Journal article

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