Journal article
Palladium-Catalyzed Decarboxylative Formal (4+2) Cycloaddition of Vinyl Benzoxazinanones with 3-Nitroindoles
Synlett, Vol.31(9), pp.916-924
2020
Abstract
A diastereoselective palladium-catalyzed dearomative formal (4+2) cycloaddition between vinyl benzoxazinanones and 3-nitroindoles has been developed. This reaction provides a concise route to tetrahydro-5H-indolo[2,3-b]quinolines in excellent yield (up to 94%) and diastereoselectivity (up to >98:2), with versatile functional handles including vinyl, nitro, and free NH groups.
Details
- Title
- Palladium-Catalyzed Decarboxylative Formal (4+2) Cycloaddition of Vinyl Benzoxazinanones with 3-Nitroindoles
- Authors
- Melissa J. Bird (Author) - University of WollongongSteven M. Wales (Author) - University of WollongongChristopher Richardson (Author) - University of WollongongChristopher J. T. Hyland (Corresponding Author) - University of Wollongong
- Publication details
- Synlett, Vol.31(9), pp.916-924
- Publisher
- Georg Thieme Verlag
- DOI
- 10.1055/s-0040-1707995
- ISSN
- 1437-2096
- Grant note
- University of Wollongong DP180101332 / Australian Research Council
- Organisation Unit
- Student Services and Engagement; School of Science, Technology and Engineering
- Language
- English
- Record Identifier
- 99707364302621
- Output Type
- Journal article
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- Chemistry, Organic
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