Oxidative stress during extracorporeal circulation

Charles Ian McDonald; J F Fraser; Jeff S Coombes; Yoke Lin Fung

doi:10.1093/ejcts/ezt637

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Oxidative stress during extracorporeal circulation

Journal article

Peer reviewed

Oxidative stress during extracorporeal circulation

Charles Ian McDonald, J F Fraser, Jeff S Coombes and Yoke Lin Fung

European Journal of Cardio-Thoracic Surgery, Vol.46(6), pp.937-943

2014

DOI: https://doi.org/10.1093/ejcts/ezt637

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Abstract

Cardiovascular Medicine and Haematology

extracorporeal circulation

cardiopulmonary bypass

ECMO

dialysis

oxidative stress

antioxidants

There is an increased oxidative stress response in patients having cardiac surgery, haemodialysis or extracorporeal membrane oxygenation that is related to poorer outcomes and increased mortality. Exposure of the patients' blood to the artificial surfaces of these extracorporeal devices, coupled with inflammatory responses, hyperoxia and the pathophysiological aspects of the underlying illness itself, all contribute to this oxidative stress response. Oxidative stress occurs when there is a disruption of redox signalling and loss of control of redox balance. Ongoing oxidative stress occurring during extracorporeal circulation (ECC) results in damage to lipids, proteins and DNA and contributes to morbidity and mortality. This review discusses reactive species generation and the potential clinical consequences of oxidative stress during ECC as well as provides an overview of some current antioxidant compounds that are available to potentially mitigate the oxidative stress response.

Details

Title: Oxidative stress during extracorporeal circulation
Authors: Charles Ian McDonald (Author) - University of Queensland
J F Fraser (Author) - University of Queensland
Jeff S Coombes (Author) - University of Queensland
Yoke Lin Fung (Author) - University of Queensland
Publication details: European Journal of Cardio-Thoracic Surgery, Vol.46(6), pp.937-943
Publisher: Oxford University Press
Date published: 2014
DOI: 10.1093/ejcts/ezt637
ISSN: 1010-7940
Organisation Unit: School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99448756602621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Cardiac & Cardiovascular Systems; Respiratory System; Surgery

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Source: InCites