Ovine enzootic abortion (OEA): A comparison of antibody responses in vaccinated and naturally-infected swiss sheep over a two year period

A Gerber; R Thoma; E Vretou; E Psarrou; C Kaiser; M G Doherr; D R Zimmermann; Adam Polkinghorne; A Pospischil; N Borel

doi:10.1186/1746-6148-3-24

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Ovine enzootic abortion (OEA): A comparison of antibody responses in vaccinated and naturally-infected swiss sheep over a two year period

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Ovine enzootic abortion (OEA): A comparison of antibody responses in vaccinated and naturally-infected swiss sheep over a two year period

A Gerber, R Thoma, E Vretou, E Psarrou, C Kaiser, M G Doherr, D R Zimmermann, Adam Polkinghorne, A Pospischil and N Borel

BMC Veterinary Research, Vol.3, 24

2007

DOI: https://doi.org/10.1186/1746-6148-3-24

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Abstract

Background: Prevention and control of ovine enzootic abortion (OEA) can be achieved by application of a live vaccine. In this study, five sheep flocks with different vaccination and infection status were serologically tested using a competitive enzyme-linked immunosorbent assay (cELISA) specific for Chlamydophila (Cp.) abortus over a two-year time period. Results: Sheep in Flock A with recent OEA history had high antibody values after vaccination similar to Flock C with natural Cp. abortus infections. In contrast, OEA serology negative sheep (Flock E) showed individual animal-specific immunoreactions after vaccination. Antibody levels of vaccinated ewes in Flock B ranged from negative to positive two and three years after vaccination, respectively. Positive antibody values in the negative control Flock D (without OEA or vaccination) are probably due to asymptomatic intestinal infections with Cp. abortus. Excretion of the attenuated strain of Cp. abortus used in the live vaccine through the eye was not observed in vaccinated animals of Flock E. Conclusion: The findings of our study indicate that, using serology, no distinction can be made between vaccinated and naturally infected sheep. As a result, confirmation of a negative OEA status in vaccinated animals by serology cannot be determined. © 2007 Gerber et al; licensee BioMed Central Ltd.

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Title: Ovine enzootic abortion (OEA): A comparison of antibody responses in vaccinated and naturally-infected swiss sheep over a two year period
Authors: A Gerber (Author) - University of Zurich, Switzerland
R Thoma (Author) - Cantonal Laboratory of Veterinary Bacteriology, Switzerland
E Vretou (Author) - Hellenic Pasteur Institute, Greece
E Psarrou (Author) - Hellenic Pasteur Institute, Greece
C Kaiser (Author) - University of Zurich, Switzerland
M G Doherr (Author) - University of Bern, Switzerland
D R Zimmermann (Author) - University Hospital, Switzerland
Adam Polkinghorne (Author) - University of Zurich, Switzerland
A Pospischil (Author) - University of Zurich, Switzerland
N Borel (Author) - University of Zurich, Switzerland
Publication details: BMC Veterinary Research, Vol.3, 24
Publisher: BioMed Central Ltd.
Date published: 2007
DOI: 10.1186/1746-6148-3-24
ISSN: 1746-6148
Copyright note: Copyright © 2007 Gerber et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Organisation Unit: University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99448727602621
Output Type: Journal article

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