Journal article
Overlap of heritable influences between cannabis use disorder, frequency of use and opportunity to use cannabis: trivariate twin modelling and implications for genetic design
Psychological Medicine, Vol.48(16), pp.2786-2793
2018
Abstract
Background: The genetic component of Cannabis Use Disorder may overlap with influences acting more generally on early stages of cannabis use. This paper aims to determine the extent to which genetic influences on the development of cannabis abuse/dependence are correlated with those acting on the opportunity to use cannabis and frequency of use. Methods: A cross-sectional study of 3303 Australian twins, measuring age of onset of cannabis use opportunity, lifetime frequency of cannabis use, and lifetime DSM-IV cannabis abuse/dependence. A trivariate Cholesky decomposition estimated additive genetic (A), shared environment (C) and unique environment (E) contributions to the opportunity to use cannabis, the frequency of cannabis use, cannabis abuse/dependence, and the extent of overlap between genetic and environmental factors associated with each phenotype. Results: Variance components estimates were A = 0.64 [95% confidence interval (CI) 0.58-0.70] and E = 0.36 (95% CI 0.29-0.42) for age of opportunity to use cannabis, A = 0.74 (95% CI 0.66-0.80) and E = 0.26 (95% CI 0.20-0.34) for cannabis use frequency, and A = 0.78 (95% CI 0.65-0.88) and E = 0.22 (95% CI 0.12-0.35) for cannabis abuse/dependence. Opportunity shares 45% of genetic influences with the frequency of use, and only 17% of additive genetic influences are unique to abuse/dependence from those acting on opportunity and frequency. Conclusions: There are significant genetic contributions to lifetime cannabis abuse/dependence, but a large proportion of this overlaps with influences acting on opportunity and frequency of use. Individuals without drug use opportunity are uninformative, and studies of drug use disorders must incorporate individual exposure to accurately identify aetiology.
Details
- Title
- Overlap of heritable influences between cannabis use disorder, frequency of use and opportunity to use cannabis: trivariate twin modelling and implications for genetic design
- Authors
- L A Hines (Corresponding Author) - King's College London, United KingdomK I Morley (Author) - King's College London, United KingdomF Rijsdijk (Author) - King's College London, United KingdomJ Strang (Author) - King's College London, United KingdomA Agrawal (Author) - Washington University School of Medicine, United StatesE C Nelson (Author) - Washington University School of Medicine, United StatesDixie J Statham (Author) - University of the Sunshine Coast - Faculty of Arts, Business and LawN G Martin (Author) - QIMR Berghofer Medical Research InstituteM T Lynskey (Author) - King's College London, United Kingdom
- Publication details
- Psychological Medicine, Vol.48(16), pp.2786-2793
- Publisher
- Cambridge University Press
- Date published
- 2018
- DOI
- 10.1017/S0033291718000478
- ISSN
- 0033-2917
- Organisation Unit
- School of Social Sciences - Legacy; University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99451426402621
- Output Type
- Journal article
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- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Psychiatry
- Psychology
- Psychology, Clinical
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