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Outcomes from Individual Alpha Frequency Guided Repetitive Transcranial Magnetic Stimulation in Children with Autism Spectrum Disorder - A Retrospective Chart Review1.50 MB
Published VersionCC BY V4.0, Open Access
Journal article
Outcomes from Individual Alpha Frequency Guided Repetitive Transcranial Magnetic Stimulation in Children with Autism Spectrum Disorder - A Retrospective Chart Review
Child Psychiatry and Human Development, Vol.55(4), pp.1010-1019
2024
PMID: 36367616
Abstract
Aims and objectives: Individual alpha frequency (IAF) is a biomarker of neurophysiological functioning. The IAF-guided repetitive transcranial magnetic stimulation (alpha-rTMS) is increasingly explored in diverse neurological conditions. However, there is limited data on the efficacy and safety of alpha-rTMS in children with autism spectrum disorder (ASD). Materials and methods: The IAF, childhood autism rating scale (CARS), Pediatric Quality of Life Inventory 4.0 (PedsQLTM 4.0), and semi-structured interview data of patients that received 19 alpha-rTMS sessions (4 weeks) were aggregated and analysed using paired student t-test and descriptive method. Results: Data were retrieved from 28 patients (26 males, aged 3-9years (mean +/- SD age: 6.1 +/- 1.8years)). The post-alpha-rTMS data shows a significant improvement in IAF (9.4 Hz; p <= 0.025) towards 10 Hz. The CARS and PedsQLTM 4.0 surveys indicate that patients' ASD symptoms and quality of life improved significantly. Specifically, reports from semi-structured interviews suggest improved sleep trouble - the most significant comorbidity. The experiences of minor side effects such as hyperactivity resolved within two hours following alpha-rTMS sessions. Conclusion: This study presents evidence on the efficacy and safety of alpha-rTMS in improving ASD symptoms, quality of life and comorbid sleep troubles in children. However, these findings should be interpreted as preliminary pending the presentation of double-blind, randomised clinical trials.
Details
- Title
- Outcomes from Individual Alpha Frequency Guided Repetitive Transcranial Magnetic Stimulation in Children with Autism Spectrum Disorder - A Retrospective Chart Review
- Authors
- Uchenna Ezedinma (Corresponding Author) - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - LegacyPiotr Swierkowski (Author) - University of the Sunshine Coast, Queensland, School of Business and Creative IndustriesShauna Fjaagesund (Author) - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - Legacy
- Publication details
- Child Psychiatry and Human Development, Vol.55(4), pp.1010-1019; 10
- Publisher
- Springer New York LLC
- Date published
- 2024
- DOI
- 10.1007/s10578-022-01461-1
- ISSN
- 1573-3327; 0009-398X
- PMID
- 36367616
- Copyright note
- This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
- Grant note
- University of the Sunshine Coast
- Organisation Unit
- School of Business and Creative Industries; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99696656602621
- Output Type
- Journal article
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