Journal article
Optimal management of the critically Ill: Anaesthesia, monitoring, data capture, and point-of-care technological practices in ovine models of critical care
BioMed Research International, 468309
2014
Abstract
Animal models of critical illness are vital in biomedical research. They provide possibilities for the investigation of pathophysiological processes that may not otherwise be possible in humans. In order to be clinically applicable, the model should simulate the critical care situation realistically, including anaesthesia, monitoring, sampling, utilising appropriate personnel skill mix, and therapeutic interventions. There are limited data documenting the constitution of ideal technologically advanced large animal critical care practices and all the processes of the animal model. In this paper, we describe the procedure of animal preparation, anaesthesia induction and maintenance, physiologic monitoring, data capture, point-of-care technology, and animal aftercare that has been successfully used to study several novel ovine models of critical illness. The relevant investigations are on respiratory failure due to smoke inhalation, transfusion related acute lung injury, endotoxin-induced proteogenomic alterations, haemorrhagic shock, septic shock, brain death, cerebral microcirculation, and artificial heart studies. We have demonstrated the functionality of monitoring practices during anaesthesia required to provide a platform for undertaking systematic investigations in complex ovine models of critical illness. © 2014 Saul Chemonges et al.
Details
- Title
- Optimal management of the critically Ill: Anaesthesia, monitoring, data capture, and point-of-care technological practices in ovine models of critical care
- Authors
- S Chemonges (Author) - University of QueenslandK Shekar (Author) - University of QueenslandJ P Tung (Author) - Red Cross Blood ServiceK R Dunster (Author) - Queensland University of TechnologyS Diab (Author) - University of QueenslandD Platts (Author) - University of QueenslandR P Watts (Author) - Prince Charles HospitalS D Gregory (Author) - University of QueenslandS Foley (Author) - University of QueenslandG Simonova (Author) - University of QueenslandC McDonald (Author) - University of QueenslandRyland Hayes (Author) - University of QueenslandJ Bellpart (Author) - University of QueenslandD Timms (Author) - Prince Charles HospitalM Chew (Author) - Prince Charles HospitalYoke Lin Fung (Author) - University of QueenslandM Toon (Author) - Prince Charles HospitalM O Maybauer (Author) - Prince Charles HospitalJ F Fraser (Author) - University of Queensland
- Publication details
- BioMed Research International, 468309; 17
- Publisher
- Hindawi Publishing Corporation
- Date published
- 2014
- DOI
- 10.1155/2014/468309
- ISSN
- 2314-6133
- Copyright note
- Copyright © 2014 Saul Chemonges et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Organisation Unit
- School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99450431902621
- Output Type
- Journal article
Metrics
16 File views/ downloads
693 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- Web Of Science research areas
- Biotechnology & Applied Microbiology
- Medicine, Research & Experimental
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites