Journal article
Onset of opportunity to use cannabis and progression from opportunity to dependence: Are influences consistent across transitions?
Drug and Alcohol Dependence, Vol.160, pp.57-64
2016
Abstract
Background: There is a developing body of research looking at cannabis use opportunity, but little research examining timing of opportunity to use cannabis. Aims: Identify factors associated with (1) earlier opportunity to use cannabis and (2) faster progression from opportunity to cannabis dependence. Method: Cross-sectional study of 3824 Australian twins and siblings, measuring age of onset of cannabis use opportunity and DSM-IV cannabis dependence. Survival analysis identified factors associated with faster progression to opportunity or dependence. Results: Factors associated with both speed of progression to opportunity and dependence were conduct disorder (opportunity HR 5.57, 95%CI 1.52-20.47; dependence HR 2.49, 95%CI 1.91-3.25), parental drug problems (opportunity HR 7.29, 95%CI 1.74-30.62; dependence HR 3.30, 95%CI 1.63-6.69), weekly tobacco use (opportunity HR 8.57, 95%CI 3.93-18.68; dependence HR 2.76, 95% CI 2.10-3.64), and female gender (opportunity HR 0.69, 95%CI 0.64-0.75; dependence HR 0.44, 95%CI 0.34-0.55). Frequent childhood religious attendance (HR 0.74, 95%CI 0.68-0.80), parental conflict (HR 1.09, 95%CI 1.00-1.18), parental alcohol problems (HR 1.19, 95%CI 1.08-1.30) and childhood sexual abuse (HR 1.17, 95%CI 1.01-1.34) were uniquely associated with transition to opportunity. Depressive episode (HR 1.44, 95%CI 1.12-1.85), tobacco dependence (HR 1.36, 95%CI 1.04-1.78), alcohol dependence (HR 2.64, 95%CI 1.53-4.58), other drug use (HR 2.10, 95%CI 1.64-2.69) and other drug dependence (HR 2.75, 95%CI 1.70-4.43) were uniquely associated with progression to dependence. Conclusion: The profile of factors associated with opportunity to use cannabis and dependence only partially overlaps, suggesting targeting of interventions may benefit from being tailored to the stages of drug use.
Details
- Title
- Onset of opportunity to use cannabis and progression from opportunity to dependence: Are influences consistent across transitions?
- Authors
- Lindsey A Hines (Author) - Kings College London, United KingdomKatherine I Morley (Author) - Kings College London, United KingdomJohn Strang (Author) - Kings College London, United KingdomArpana Agrawal (Author) - Washington University School of Medicine, United StatesElliot C Nelson (Author) - Washington University School of Medicine, United StatesDixie J Statham (Author) - University of the Sunshine Coast - Faculty of Arts, Business and LawNicholas G Martin (Author) - QIMR Berghofer Medical Research InstituteMichael T Lynskey (Author) - Kings College London, United Kingdom
- Publication details
- Drug and Alcohol Dependence, Vol.160, pp.57-64
- Publisher
- Elsevier Ireland Ltd.
- Date published
- 2016
- DOI
- 10.1016/j.drugalcdep.2015.12.032
- ISSN
- 0376-8716
- Copyright note
- Copyright © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
- Organisation Unit
- School of Social Sciences - Legacy; University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99450205002621
- Output Type
- Journal article
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