Olfactory Neuroblastoma in Dogs and Cats - a Histological and Immunohistochemical Analysis

K Brosinski; D Janik; Adam Polkinghorne; W Von Bomhard; W Schmahl

doi:10.1016/j.jcpa.2011.06.002

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Olfactory Neuroblastoma in Dogs and Cats - a Histological and Immunohistochemical Analysis

Journal article

Peer reviewed

Olfactory Neuroblastoma in Dogs and Cats - a Histological and Immunohistochemical Analysis

K Brosinski, D Janik, Adam Polkinghorne, W Von Bomhard and W Schmahl

Journal of Comparative Pathology, Vol.146(2-3), pp.152-159

2012

DOI: https://doi.org/10.1016/j.jcpa.2011.06.002

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Abstract

cat

dog

immunohistochemistry

olfactory neuroblastoma

Olfactory neuroblastoma (ONB) was identified in 13 dogs and nine cats. The tumours were subjected to microscopical examination and were graded using a human pathological grading system. In the canine and feline tumours there was more necrosis and higher mitotic activity (mitotic index and Ki67 labelling index) than reported in human ONB. Rosettes were a common feature of feline ONBs. A significant correlation was observed between the histological grade and the Ki67 labelling index. The histopathological diagnosis of ONB was confirmed immunohistochemically by demonstration of the neuronal marker neuron-specific enolase (NSE). Two other neuron-specific antibodies specific for microtubule-associated protein-2 (MAP-2) and neuronal nuclei antigen (NeuN) were evaluated. MAP-2 expression proved to have higher specificity than labelling for NSE. NeuN expression was less sensitive and of limited practical value. © 2011 Elsevier Ltd.

Details

Title: Olfactory Neuroblastoma in Dogs and Cats - a Histological and Immunohistochemical Analysis
Authors: K Brosinski (Author) - Ludwig-Maximillians University, Germany
D Janik (Author) - Ludwig-Maximillians University, Germany
Adam Polkinghorne (Author) - Queensland University of Technology
W Von Bomhard (Author) - Speciality Practice for Veterinary Pathology, Germany
W Schmahl (Author) - Ludwig-Maximillians University, Germany
Publication details: Journal of Comparative Pathology, Vol.146(2-3), pp.152-159
Publisher: Elsevier Ltd.
Date published: 2012
DOI: 10.1016/j.jcpa.2011.06.002
ISSN: 0021-9975
Organisation Unit: University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99448873302621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Pathology; Veterinary Sciences

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