Off-pump Coronary Artery Bypass Surgery Induces Prolonged Alterations to Host Neutrophil Physiology

J James B Edelman; Yoke Lin Fung; Gabrielle J Pennings; Caroline J Reddel; Paul G Bannon; Matthew S Bayfield; Leonard Kritharides; John F Fraser; Michael P Vallely

doi:10.1097/SHK.0b013e31827c2aba

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Off-pump Coronary Artery Bypass Surgery Induces Prolonged Alterations to Host Neutrophil Physiology

Journal article

Peer reviewed

Off-pump Coronary Artery Bypass Surgery Induces Prolonged Alterations to Host Neutrophil Physiology

J James B Edelman, Yoke Lin Fung, Gabrielle J Pennings, Caroline J Reddel, Paul G Bannon, Matthew S Bayfield, Leonard Kritharides, John F Fraser and Michael P Vallely

Shock, Vol.39(2), pp.149-154

2013

DOI: https://doi.org/10.1097/SHK.0b013e31827c2aba

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Abstract

neutrophils

off-pump coronary artery bypass grafting

systemic inflammatory response syndrome

cardiopulmonary bypass

immunocompromise

ABSTRACT: Persistent alteration to host polymorphonuclear cell (PMN) physiology has been demonstrated after cardiac surgery performed with cardiopulmonary bypass (CPB). However, to date, PMN physiology and function beyond the first 24 h have not been investigated after cardiac surgery performed without CPB (off-pump coronary artery bypass grafting [OPCAB]). Blood samples of 15 patients were collected preoperatively and on days 1, 3, and 5 after OPCAB. Expression of CD11b, CD18, CBRM1/5, and CD62L were assessed by flow cytometry under resting conditions and after stimulation with formyl methionyl-leucyl-phenylalanine (fMLF), and respiratory burst activity was also measured. Under resting conditions, PMN CD11b, CBRM1/5, and CD62L expressions were minimally altered by surgery. Compared with the response of preoperative PMNs, PMNs assayed on days 3 and 5 after OPCAB demonstrated a significantly blunted increase in the expression of CD11b and CBRM1/5 after fMLF, significantly diminished shedding of CD62L in response to platelet-activating factor and fMLF, and diminished superoxide production after stimulation on day 3. The alteration of PMN function after OPCAB implies that cardiac surgical trauma without CPB directly modulates host PMN physiology.

Details

Title: Off-pump Coronary Artery Bypass Surgery Induces Prolonged Alterations to Host Neutrophil Physiology
Authors: J James B Edelman (Author) - University of Sydney
Yoke Lin Fung (Author) - University of Queensland
Gabrielle J Pennings (Author) - University of Sydney
Caroline J Reddel (Author) - University of Sydney
Paul G Bannon (Author) - University of Sydney
Matthew S Bayfield (Author) - University of Sydney
Leonard Kritharides (Author) - University of Sydney
John F Fraser (Author) - University of Queensland
Michael P Vallely (Author) - University of Sydney
Publication details: Shock, Vol.39(2), pp.149-154
Publisher: Lippincott Williams & Wilkins
Date published: 2013
DOI: 10.1097/SHK.0b013e31827c2aba
ISSN: 1073-2322
Organisation Unit: School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99449032402621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Critical Care Medicine; Hematology; Peripheral Vascular Disease; Surgery

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