Observational study of the microcirculation in patients with liver cirrhosis

Stephen Wythe; Thomas W Davies; James O'Beirne; Daniel Martin; Edward Gilbert-Kawai

doi:10.1002/jgh3.12196

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Observational study of the microcirculation in patients with liver cirrhosis

Journal article

Open access

Peer reviewed

Observational study of the microcirculation in patients with liver cirrhosis

Stephen Wythe, Thomas W Davies, James O'Beirne, Daniel Martin and Edward Gilbert-Kawai

JGH Open, Vol.3(6), pp.518-524

2019

DOI: https://doi.org/10.1002/jgh3.12196

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Abstract

cirrhosis

hepatology

incident dark field imaging

microcirculation

near infra-red spectroscopy

video microscopy

Background and Aim: Liver cirrhosis is associated with widespread microcirculatory dysfunction and hemodynamic derangement, which may play a role in the pathogenesis of multiple organ failure. Little is known, however, about the progression of microvascular alterations as the severity of liver disease worsens. Therefore, our aim is to quantify the peripheral systemic microcirculatory changes associated with increasing severity of liver cirrhosis. Methods: Forty patients with liver cirrhosis were studied and divided into groups based on Child-Pugh classes A (n = 9), B (n = 18), and C (n = 13) for comparison. Incident dark ï¬eld imaging was used to evaluate the sublingual microcirculation and near-infrared spectroscopy at the thenar eminence to assess microvascular reactivity and function. Results: There was no difference in microcirculatory ï¬‚ow index (P = 0.655), heterogeneity index (P = 0.702), or vessel density (P = 0.923) between the different ChildPugh groups. Microvascular reactivity did not change as the severity of liver disease worsened. Conclusions: This study showed no association between peripheral systemic microcirculatory alterations and the severity of liver disease. Further research with larger study cohorts are needed to clarify the relationship between microcirculatory abnormalities and disease progression and to establish if the peripheral microcirculation is affected by the pathophysiology of worsening cirrhosis.

Details

Title: Observational study of the microcirculation in patients with liver cirrhosis
Authors: Stephen Wythe (Corresponding Author) - University College London
Thomas W Davies (Author) - University College London
James O'Beirne (Author) - University of the Sunshine Coast
Daniel Martin (Author) - University College London
Edward Gilbert-Kawai (Author) - University College London
Publication details: JGH Open, Vol.3(6), pp.518-524
Publisher: Wiley-Blackwell Publishing Asia
Date published: 2019
DOI: 10.1002/jgh3.12196
ISSN: 2397-9070
Copyright note: Copyright © 2019 The Authors. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99450747902621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Gastroenterology & Hepatology

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