Objective sleep measures in chronic fatigue syndrome patients: A systematic review and meta-analysis

Abdalla Z. Mohamed; Thu Andersen; Sanja Radovic; Peter Del Fante; Richard Kwiatek; Vince Calhoun; Sandeep Bhuta; Daniel F. Hermens; Jim Lagopoulos; Zack Y. Shan

doi:10.1016/j.smrv.2023.101771

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Objective sleep measures in chronic fatigue syndrome patients: A systematic review and meta-analysis

Journal article

Peer reviewed

Objective sleep measures in chronic fatigue syndrome patients: A systematic review and meta-analysis

Abdalla Z. Mohamed, Thu Andersen, Sanja Radovic, Peter Del Fante, Richard Kwiatek, Vince Calhoun, Sandeep Bhuta, Daniel F. Hermens, Jim Lagopoulos and Zack Y. Shan

Sleep Medicine Reviews, Vol.69, pp.1-14

2023

DOI: https://doi.org/10.1016/j.smrv.2023.101771

PMCID: PMC10281648

PMID: 36948138

Appears in Thompson Institute Research Collection

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Abstract

Actigraphy watch

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

Objective measurements

Polysomnography (PSG)

Sleep

Systematic review

Chronic fatigue syndrome

Thompson Institute Special Collection

Patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) often report disrupted and unrefreshing sleep in association with worsened fatigue symptoms. However, the nature and magnitude of sleep architecture alteration in ME/CFS is not known, with studies using objective sleep measures in ME/CFS generating contradictory results. The current manuscript aimed to review and meta analyse of case control studies with objective sleep measures in ME/CSF. A search was conducted in PubMed, Scopus, Medline, Google Scholar, and Psychoinfo databases. After review, 24 studies were included in the meta analysis, including 20 studies with 801 adults (ME/CFS = 426; controls = 375), and 4 studies with 477 adolescents (ME/CFS = 242; controls = 235), who underwent objective measurement of sleep. Adult ME/CFS patients spend longer time in bed, longer sleep onset latency, longer awake time after sleep onset, reduced sleep efficiency, decreased stage 2 sleep, more Stage 3, and longer rapid eye movement sleep latency. However, adolescent ME/CFS patients had longer time in bed, longer total sleep time, longer sleep onset latency, and reduced sleep efficiency. The meta analysis results demonstrate that sleep is altered in ME/CFS, with changes seeming to differ between adolescent and adults, and suggesting sympathetic and parasympathetic nervous system alterations in ME/CFS.

Details

Title: Objective sleep measures in chronic fatigue syndrome patients: A systematic review and meta-analysis
Authors: Abdalla Z. Mohamed (Corresponding Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Thu Andersen (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Sanja Radovic (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Peter Del Fante (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Richard Kwiatek (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Vince Calhoun (Author) - Georgia State University
Sandeep Bhuta (Author) - Gold Coast Hospital
Daniel F. Hermens (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Jim Lagopoulos (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Zack Y. Shan (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Publication details: Sleep Medicine Reviews, Vol.69, pp.1-14
Publisher: Elsevier Masson
Date published: 2023
DOI: 10.1016/j.smrv.2023.101771
ISSN: 1532-2955
PMID: 36948138; PMC10281648
Grants: Multimodal MRI of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Understanding its Neuropathophysiology and Developing an Objective Neuromarker, 1184219, National Health and Medical Research Council (Australia, Canberra) - NHMRC
A neurobiology based model of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome with advanced neuroimaging, MAS2018F00019, The Mason Foundation
A multimodal neuromarker of myalgic encephalomyelitis/chronic fatigue syndrome, MAS2018F00024, The Mason Foundation
Grant note: 2112455 / National Institutes of Health; R01MH118695 / National Institutes of Health.
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99715098502621
Output Type: Journal article

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