Journal article
Objective sleep measures in chronic fatigue syndrome patients: A systematic review and meta-analysis
Sleep Medicine Reviews, Vol.69, pp.1-14
2023
Appears in Thompson Institute Research Collection
Abstract
Patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) often report disrupted and unrefreshing sleep in association with worsened fatigue symptoms. However, the nature and magnitude of sleep architecture alteration in ME/CFS is not known, with studies using objective sleep measures in ME/CFS generating contradictory results. The current manuscript aimed to review and meta analyse of case control studies with objective sleep measures in ME/CSF. A search was conducted in PubMed, Scopus, Medline, Google Scholar, and Psychoinfo databases. After review, 24 studies were included in the meta analysis, including 20 studies with 801 adults (ME/CFS = 426; controls = 375), and 4 studies with 477 adolescents (ME/CFS = 242; controls = 235), who underwent objective measurement of sleep. Adult ME/CFS patients spend longer time in bed, longer sleep onset latency, longer awake time after sleep onset, reduced sleep efficiency, decreased stage 2 sleep, more Stage 3, and longer rapid eye movement sleep latency. However, adolescent ME/CFS patients had longer time in bed, longer total sleep time, longer sleep onset latency, and reduced sleep efficiency. The meta analysis results demonstrate that sleep is altered in ME/CFS, with changes seeming to differ between adolescent and adults, and suggesting sympathetic and parasympathetic nervous system alterations in ME/CFS.
Details
- Title
- Objective sleep measures in chronic fatigue syndrome patients: A systematic review and meta-analysis
- Authors
- Abdalla Z. Mohamed (Corresponding Author) - University of the Sunshine Coast, Queensland, Thompson InstituteThu Andersen (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteSanja Radovic (Author) - University of the Sunshine Coast, Queensland, Thompson InstitutePeter Del Fante (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteRichard Kwiatek (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteVince Calhoun (Author) - Georgia State UniversitySandeep Bhuta (Author) - Gold Coast HospitalDaniel F. Hermens (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteJim Lagopoulos (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteZack Y. Shan (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
- Publication details
- Sleep Medicine Reviews, Vol.69, pp.1-14
- Publisher
- Elsevier Masson
- Date published
- 2023
- DOI
- 10.1016/j.smrv.2023.101771
- ISSN
- 1532-2955
- Grants
- A neurobiology based model of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome with advanced neuroimaging, MAS2018F00019, The Mason FoundationA multimodal neuromarker of myalgic encephalomyelitis/chronic fatigue syndrome, MAS2018F00024, The Mason Foundation
- Grant note
- 2112455 / National Institutes of Health; R01MH118695 / National Institutes of Health.
- Organisation Unit
- University of the Sunshine Coast, Queensland; Thompson Institute
- Language
- English
- Record Identifier
- 99715098502621
- Output Type
- Journal article
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