Journal article
Nutraceuticals in patients with heart failure: A systematic review
Journal of Cardiac Failure, Vol.26(2), pp.166-179
2020
Abstract
Background: Nutraceuticals are pharmacologically active substances extracted from vegetable or animal food and administered to produce health benefits. We recently reviewed the current evidence for nutraceuticals in patients diagnosed with heart failure as part of the writing of the Australian Guidelines for the prevention, diagnosis and management of heart failure. Methods: A systematic search for studies that compared nutraceuticals to standard care in adult patients with heart failure was performed. Studies were included if > 50 patients were enrolled, with ≥6 months follow up. If no studies met criteria then studies < 50 patients and < 6 months follow up were included. The primary outcomes included mortality/survival, hospitalisation, quality of life, and/or exercise tolerance. Iron was not included in this review as its role in HF is already well established. Results: Forty studies met the inclusion criteria. The strongest evidence came from studies of polyunsaturated fatty acids, which modestly decreased mortality and cardiovascular hospitalisations in patients with mostly New York Heart Association (NYHA) II and III heart failure across a range of left ventricular ejection fraction. Co-enzyme Q10 may decrease mortality and hospitalisation, but definite conclusions cannot be drawn. Studies that examined nitrate rich beetroot juice, micronutrient supplementation, hawthorn extract, magnesium, thiamine, vitamin E, vitamin D, L-arginine, L-carnosine and L-carnitine were too small or underpowered to properly appraise clinical outcomes. Conclusion: Only one nutraceutical, omega-3 PUFA, received a positive recommendation in the Australian heart failure guidelines. Although occasionally showing some promise, all other nutraceuticals are inadequately studied to allow any conclusion on efficacy. Clinicians should favour other treatments that have been clearly shown to decrease mortality.
Details
- Title
- Nutraceuticals in patients with heart failure: A systematic review
- Authors
- Ingrid Hopper (Author) - Monash UniversityCia Connell (Author) - National Heart Foundation of AustraliaTom Briffa (Author) - University of Western AustraliaCarmine G Depasquale (Author) - Flinders UniversityAndrea Driscoll (Author) - Austin HealthPeter M Kistler (Author) - Alfred HospitalPeter S Macdonald (Author) - University of New South WalesAndrew Sindone (Author) - University of SydneyLiza Thomas (Author) - University of SydneyJohn J Atherton (Author) - University of Queensland
- Publication details
- Journal of Cardiac Failure, Vol.26(2), pp.166-179
- Publisher
- Elsevier Inc.
- Date published
- 2020
- DOI
- 10.1016/j.cardfail.2019.10.014
- ISSN
- 1071-9164; 1071-9164
- Organisation Unit
- University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99451401602621
- Output Type
- Journal article
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- Domestic collaboration
- Web Of Science research areas
- Cardiac & Cardiovascular Systems
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Source: InCites