Journal article
Nucleocytoplasmic transport as a driver of mammalian gametogenesis
Seminars in Cell and Developmental Biology, Vol.20(5), pp.607-619
2009
Abstract
Adult fertility requires appropriate and coordinated instruction of somatic and germ cell activity during lineage specification, development and maturation. Driven by alterations in the complement of nuclear proteins such as transcription factors and chromatin remodelling components, these events proceed by sequential changes in gene expression in response to a myriad of signalling cues. Controlled access of proteins to the nucleus is a key driver of developmental switches. This review discusses key examples of regulated nucleocytoplasmic transport during mammalian gametogenesis and the mechanisms underpinning these transport events, focusing on examples critical for the establishment of fertility. © 2009 Elsevier Ltd. All rights reserved.
Details
- Title
- Nucleocytoplasmic transport as a driver of mammalian gametogenesis
- Authors
- Catherine Itman (Author) - Monash UniversityY Miyamoto (Author) - Monash UniversityJ C Young (Author) - Monash UniversityD A Jans (Author) - Monash UniversityK L Loveland (Author) - Monash University
- Publication details
- Seminars in Cell and Developmental Biology, Vol.20(5), pp.607-619
- Publisher
- Academic Press
- Date published
- 2009
- DOI
- 10.1016/j.semcdb.2009.05.002
- ISSN
- 1084-9521
- Organisation Unit
- University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99449928302621
- Output Type
- Journal article
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