Non-viable human embryos as a source of viable cells for embryonic stem cell derivation

S Gavrilov; R W Prosser; I Khalid; Joanne Macdonald; M V Sauer; D W Landry; V E Papaioannou

doi:10.1016/S1472-6483(10)60270-2

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Non-viable human embryos as a source of viable cells for embryonic stem cell derivation

Journal article

Peer reviewed

Non-viable human embryos as a source of viable cells for embryonic stem cell derivation

S Gavrilov, R W Prosser, I Khalid, Joanne Macdonald, M V Sauer, D W Landry and V E Papaioannou

Reproductive BioMedicine Online, Vol.18(2), pp.301-308

2009

DOI: https://doi.org/10.1016/S1472-6483(10)60270-2

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Abstract

ES cell derivation

hESC

human embryonic stem cells

non-viable human embryos

Human embryonic stem cells (hESC) hold great promise for use in regenerative medicine. However, the extraordinary potential of hESC as therapeutic tools is tempered by ethical, moral and political issues surrounding their derivation from human embryos. It has previously been proposed that ethical criteria applied to essential organ donation could be employed for derivation of hESC from irreversibly arrested, and thus organismically dead, human embryos produced during routine IVF procedures. Here, it is shown that arrested embryos do not resume normal development during extended culture, yet most of them contain a substantial number of living cells on embryonic day 6 (72% have >1 viable cell, 47% have >5 viable cells), suggesting that this class of non-viable embryos could be a rich source of viable cells for derivation of hESC lines.

Details

Title: Non-viable human embryos as a source of viable cells for embryonic stem cell derivation
Authors: S Gavrilov (Author) - Columbia University, United States
R W Prosser (Author) - Columbia University, United States
I Khalid (Author) - Columbia University, United States
Joanne Macdonald (Author) - Columbia University, United States
M V Sauer (Author) - Columbia University, United States
D W Landry (Author) - Columbia University, United States
V E Papaioannou (Author) - Columbia University, United States
Publication details: Reproductive BioMedicine Online, Vol.18(2), pp.301-308
Publisher: Elsevier Ltd.
Date published: 2009
DOI: 10.1016/S1472-6483(10)60270-2
ISSN: 1472-6483
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99450497802621
Output Type: Journal article

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