Journal article
Non-linear reduction in hyperautofluorescent ring area in retinitis pigmentosa
Ophthalmology Retina, Vol.8(3), pp.298-306
2024
Abstract
PURPOSE: To report baseline dimension of the autofluorescent (AF) ring in a large cohort of retinitis pigmentosa (RP) patients and to evaluate models of ring progression.
DESIGN: Cohort study
PARTICIPANTS: Four hundred and forty-five eyes of 224 patients with clinical diagnosis of RP.
METHODS: AF rings from near-infrared AF (NIRAF) and short wavelength AF (SWAF) imaging modalities in RP eyes were segmented with ring area and horizontal extent extracted for each image for
cross-sectional and longitudinal analyses. In longitudinal analysis, for each eye, ring area, horizontal extent and natural logarithm of the ring area were assessed as the best dependant variable for linear regression by evaluating R2 values. Linear mixed-effects modelling was utilized to account for inter-eye correlation.
MAIN OUTCOME MEASURES: AF ring size characteristics at baseline and ring progression rates.
RESULTS: A total of 439 eyes had SWAF imaging at baseline with the AF ring observed in 206 (46.9%) eyes. Mean (95% CI) of ring area and horizontal extent were 7.85 (6.60 to 9.11) mm2 and 3.35 (3.10 to 3.60) mm, respectively. In NIRAF, the mean ring area and horizontal extent were 7.74 (6.60 to 8.89) mm2 and 3.26 (3.02 to 3.50) mm, respectively in 251 out of 432 eyes. Longitudinal analysis showed mean progression rates of -0.57 mm2/year and -0.12 mm/year in SWAF using area and horizontal extent as the dependent variable, respectively. When ln(Area) was analysed as the dependant variable, mean progression was -0.07 ln(mm2)/year which equates to 6.80% decrease in ring area per year. Similar rates were found in NIRAF (area: -0.59 mm2/year, horizontal extent: -0.12mm/year and ln(Area): -0.08 ln(mm2)/year equating to 7.75% decrease in area per year). Analysis of R2 showed that the dependent variable ln(Area) provided the best linear model for ring progression in both imaging modalities, especially in eyes with large overall area change.
CONCLUSIONS: Our data suggests that using an exponential model to estimate progression of the AF ring area in RP is more appropriate than the models assuming linear decrease. Hence the progression estimates provided in this study should provide more accurate reference points in designing RP clinical trials.
Details
- Title
- Non-linear reduction in hyperautofluorescent ring area in retinitis pigmentosa
- Authors
- Jason Charng (Author) - University of Western AustraliaIgnacio Andres Viedma Escalona (Author) - Queensland University of TechnologyAndrew Turpin (Author) - University of Western AustraliaAllison M. McKendrick (Author) - University of Western AustraliaDavid A. Mackey (Author) - University of Western AustraliaDavid Alonso-Caneiro (Author) - University of the Sunshine Coast, Queensland, School of Science, Technology and EngineeringFred K. Chen (Author) - University of Western Australia
- Publication details
- Ophthalmology Retina, Vol.8(3), pp.298-306
- Publisher
- Elsevier Inc.
- DOI
- 10.1016/j.oret.2023.09.015
- Grant note
- Australian Vision Research WA Health Near-miss Award Telethon-Perth Children’s Hospital Research Fund Miocevich Family grant McCusker Foundation grant Australian National Health & Medical Research Council Career Development Fellowship Centre of Research Excellence grant
- Organisation Unit
- School of Science, Technology and Engineering; University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99971198202621
- Output Type
- Journal article
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