Journal article
Nocturnal Hypoxemia Is Associated with Altered Parahippocampal Functional Brain Connectivity in Older Adults at Risk for Dementia
Journal of Alzheimer's Disease, Vol.73(2), pp.571-584
2020
Appears in Thompson Institute Research Collection
Abstract
Background:Obstructive sleep apnea is associated with an increased risk of developing mild cognitive impairment and dementia. Intermittent nocturnal hypoxemia in obstructive sleep apnea is associated with brain changes in key regions that underpin memory. Objective:To determine whether older adults with severe nocturnal hypoxemia would exhibit reduced functional connectivity within these regions, with associated deficits in memory. Methods:Seventy-two participants 51 years and over underwent polysomnography with continuous blood oxygen saturation recorded via oximetry. The oxygen desaturation index (ODI, 3% dips in oxygen levels per hour) was the primary outcome measure. ODI was split into tertiles, with analyses comparing the lowest and highest tertiles (N = 48). Thirty-five of the 48 participants from these two tertiles had mild cognitive impairment. Participants also underwent resting-state fMRI and comprehensive neuropsychological, medical, and psychiatric assessment. Results:The highest ODI tertile group demonstrated significantly reduced connectivity between the left and right parahippocampal cortex, relative to the lowest ODI tertile group (t(42) = -3.26, p = 0.041, beta = -1.99).The highest ODI tertile group also had poorer working memory performance. In the highest ODI tertile group only, higher left-right parahippocampal functional connectivity was associated with poorer visual memory recall (between-groups z = -2.93, p = 0.0034). Conclusions:Older adults with severe nocturnal hypoxemia demonstrate impaired functional connectivity in medial temporal structures, key regions involved in sleep memory processing and implicated in dementia pathophysiology. Oxygen desaturation and functional connectivity in these individuals each relate to cognitive performance. Research is now required to further elucidate these findings.
Details
- Title
- Nocturnal Hypoxemia Is Associated with Altered Parahippocampal Functional Brain Connectivity in Older Adults at Risk for Dementia
- Authors
- Sharon L Naismith (Author) - The University of SydneyShantel L Duffy (Author) - The University of SydneyNathan Cross (Author) - The University of SydneyRon Grunstein (Author) - Woolcock Institute of Medical ResearchZoe Terpening (Author) - The University of SydneyCamilla Hoyos (Author) - The University of SydneyAngela D'Rozario (Author) - The University of SydneyJim Lagopoulos (Author) - University of the Sunshine Coast - Thompson InstituteRicardo S Osorio (Author) - New York University School of MedicineJames M Shine (Author) - The University of SydneyAndrew C McKinnon (Author) - The University of Sydney
- Publication details
- Journal of Alzheimer's Disease, Vol.73(2), pp.571-584
- Publisher
- IOS Press
- Date published
- 2020
- DOI
- 10.3233/JAD-190747
- ISSN
- 1387-2877
- Organisation Unit
- University of the Sunshine Coast, Queensland; Thompson Institute
- Language
- English
- Record Identifier
- 99450951102621
- Output Type
- Journal article
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