No evidence of a legacy effect on survival following randomization to extended hours dialysis in the ACTIVE Dialysis trial

Brendan Smyth; Li Zuo; Nicholas Gray; Christopher T Chan; Janak R Zoysa; Daqing Hong; Kris Rogers; Jia Wang; Alan Cass; Martin Gallagher; Vlado Perkovic; Meg Jardine; ACTIVE Dialysis Study Investigators

doi:10.1111/nep.13737

Back

No evidence of a legacy effect on survival following randomization to extended hours dialysis in the ACTIVE Dialysis trial

Journal article

Peer reviewed

No evidence of a legacy effect on survival following randomization to extended hours dialysis in the ACTIVE Dialysis trial

Brendan Smyth, Li Zuo, Nicholas Gray, Christopher T Chan, Janak R Zoysa, Daqing Hong, Kris Rogers, Jia Wang, Alan Cass, Martin Gallagher, …

Nephrology, Vol.25(10), pp.792-800

2020

DOI: https://doi.org/10.1111/nep.13737

Files and links (1)

url

https://doi.org/10.1111/nep.13737View

Published Version

Abstract

dialysis

end-stage kidney disease

haemodialysis

randomized controlled trial

Aim: Extended hours haemodialysis is associated with superior survival to standard hours. However, residual confounding limits the interpretation of this observation. We aimed to determine the effect of a period of extended hours dialysis on long-term survival among participants in the ACTIVE Dialysis trial. Methods: Two-hundred maintenance haemodialysis recipients were randomized to extended hours dialysis (median 24 h/wk) or standard hours dialysis (median 12 h/ wk) for 12 months. Further pre-specified observational follow up occurred at 24, 36 and 60 months. Vital status and modality of renal replacement therapy were ascertained. Results: Over the 5 years, 38 participants died, 30 received a renal transplant, and 6 were lost to follow up. Total weekly dialysis hours did not differ between standard and extended groups during the follow-up period (14.1 hours [95%CI 13.4-14.8] vs 14.8 hours [95%CI 14.1-15.6]; P = .16). There was no difference in all-cause mortality (hazard ratio for extended hours 0.91 [95%CI 0.48-1.72]; P = .77). Similar results were

Details

Title: No evidence of a legacy effect on survival following randomization to extended hours dialysis in the ACTIVE Dialysis trial
Authors: Brendan Smyth (Corresponding Author) - University of Sydney
Li Zuo (Author) - Peking University
Nicholas Gray (Author) - University of the Sunshine Coast, Queensland, USC Clinical Trials Centre - Legacy
Christopher T Chan (Author) - University Health Network
Janak R Zoysa (Author) - University of Auckland
Daqing Hong (Author) - University of Electronic Science and Technology of China
Kris Rogers (Author) - UNSW Australia
Jia Wang (Author) - University of Electronic Science and Technology of China
Alan Cass (Author) - Charles Darwin University
Martin Gallagher (Author) - Concord Repatriation General Hospital
Vlado Perkovic (Author) - UNSW Australia
Meg Jardine (Author) - UNSW Australia
ACTIVE Dialysis Study Investigators (Author)
Publication details: Nephrology, Vol.25(10), pp.792-800
Publisher: Wiley-Blackwell Publishing Asia
DOI: 10.1111/nep.13737
ISSN: 1440-1797
Organisation Unit: School of Health and Behavioural Sciences - Legacy; School of Health and Sport Sciences - Legacy; UniSC Clinical Trials Centre; University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99468007802621
Output Type: Journal article

Metrics

18 Record Views

3 Times Cited - Web of Science

See more details

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Urology & Nephrology

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites