Files and links (2)
No effect of modest selenium supplementation on insulin resistance in UK pregnant women, as assessed by plasma adiponectin concentration262.72 kB
Published VersionCC BY V4.0, Open Access
Journal article
No effect of modest selenium supplementation on insulin resistance in UK pregnant women, as assessed by plasma adiponectin concentration
British Journal of Nutrition, Vol.115(1), pp.32-38
2016
PMID: 26481811
Abstract
Concern has been expressed recently that Se may increase the risk of type 2 diabetes, but this has not been tested in a randomised-controlled trial (RCT) in pregnant women. We took advantage of having stored plasma samples from the Se in Pregnancy Intervention (SPRINT) RCT of Se supplementation in pregnancy to test the effect of Se supplementation on a marker of insulin resistance in UK pregnant women. Because our blood samples were not fasted, we measured plasma adiponectin concentration, a recognised marker of insulin resistance that gives valid measurements in non-fasted samples, as diurnal variability is minor and there is no noticeable effect of food intake. In SPRINT, 230 primiparous UK women were randomised to treatment with Se (60 mu g/d) or placebo from 12 weeks of gestation until delivery. We hypothesised that supplementation with Se at a nutritional level would not exacerbate the fall in adiponectin concentration that occurs in normal pregnancy, indicating the lack of an adverse effect on insulin resistance. Indeed, there was no significant difference between the two groups in the change in adiponectin from 12 to 35 weeks (P=0.938), nor when the analysis was restricted to the bottom or top quartiles of baseline whole-blood Se (P = 0.515 and 0.858, respectively). Cross-sectionally, adiponectin concentration was not associated with any parameter of Se status, either at 12 or 35 weeks. It is reassuring that a nutritional dose of Se had no adverse effect on the concentration of adiponectin, a biomarker of insulin resistance, in pregnant women of modest Se status.
Details
- Title
- No effect of modest selenium supplementation on insulin resistance in UK pregnant women, as assessed by plasma adiponectin concentration
- Authors
- Jinyuan Mao (Corresponding Author) - First Hospital of China Medical UniversitySarah C. Bath (Author) - University of SurreyJessica J. Vanderlelie (Author) - Griffith UniversityAnthony V. Perkins (Author) - Griffith UniversityChristopher W. G. Redman (Author) - University of OxfordMargaret P. Rayman (Author) - University of Surrey
- Publication details
- British Journal of Nutrition, Vol.115(1), pp.32-38
- Publisher
- Cambridge University Press
- Date published
- 2016
- DOI
- 10.1017/S0007114515004067
- ISSN
- 1475-2662; 0007-1145
- PMID
- 26481811
- Copyright note
- © The Authors 2015. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Grant note
- F12-193-9-28 / Shenyang Science and Technology Project MRC Population Health Scientist Fellowship; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) MR/K02132X/1 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) 283883 / European Commission under the 7th Framework Programme through the 'Research Infrastructures' action of the 'Capacities' Programme (NMI3-II) MR/K02132X/1 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission 083918/Z/07/Z / Wellcome Trust; European Commission
- Organisation Unit
- School of Health; University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99685195402621
- Output Type
- Journal article
Metrics
2 File views/ downloads
26 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Nutrition & Dietetics
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites