No association between mannose-binding lectin deficiency and H1N1 2009 infection observed during the first season of this novel pandemic influenza virus

Damon P Eisen; Caroline L Marshall; Melinda M Dean; Joe Sasadeusz; Michael P Richards; Kirsty Buising; Allen Cheng; Paul D R Johnson; Ian G Barr; Emma S McBryde

doi:10.1016/j.humimm.2011.08.014

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No association between mannose-binding lectin deficiency and H1N1 2009 infection observed during the first season of this novel pandemic influenza virus

Journal article

Peer reviewed

No association between mannose-binding lectin deficiency and H1N1 2009 infection observed during the first season of this novel pandemic influenza virus

Damon P Eisen, Caroline L Marshall, Melinda M Dean, Joe Sasadeusz, Michael P Richards, Kirsty Buising, Allen Cheng, Paul D R Johnson, Ian G Barr and Emma S McBryde

Human Immunology, Vol.72(11), pp.1091-1094

2011

DOI: https://doi.org/10.1016/j.humimm.2011.08.014

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Abstract

Deficiency

Influenza

Innate immunity

Mannose-binding lectin

Pandemic

mannose binding lectin

Genetic variations in host immunity may influence susceptibility to novel infections like the recently emergent pandemic influenza virus. Prior studies demonstrated that mannose-binding lectin (MBL) inactivates influenza. Furthermore, MBL deficiency is common and appears to predispose to respiratory virus infections. Therefore, we studied whether MBL deficiency played a role in infection with the novel H1N1 2009 influenza strain in exposed health care workers. In a nested case-control study, we observed no association between phenotypic MBL deficiency, variously defined, and predisposition to H1N1 2009 influenza in 63 pairs of seropositive and seronegative participants. MBL appears to currently have little impact on innate immune responses to H1N1 2009 influenza.

Details

Title: No association between mannose-binding lectin deficiency and H1N1 2009 infection observed during the first season of this novel pandemic influenza virus
Authors: Damon P Eisen (Author) - The Royal Melbourne Hospital
Caroline L Marshall (Author) - The Royal Melbourne Hospital
Melinda M Dean (Author) - Australian Red Cross Blood Service
Joe Sasadeusz (Author) - The Royal Melbourne Hospital
Michael P Richards (Author) - The Royal Melbourne Hospital
Kirsty Buising (Author) - St Vincent's Hospital Melbourne
Allen Cheng (Author) - Alfred Hospital
Paul D R Johnson (Author) - Austin Health
Ian G Barr (Author) - World Health Organization
Emma S McBryde (Author) - The Royal Melbourne Hospital
Publication details: Human Immunology, Vol.72(11), pp.1091-1094
Publisher: Elsevier Inc.
Date published: 2011
DOI: 10.1016/j.humimm.2011.08.014
ISSN: 0198-8859; 0198-8859
Organisation Unit: School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99513884902621
Output Type: Journal article

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Web Of Science research areas: Immunology

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