Nineteen and up study (19Up): Understanding pathways to mental health disorders in young Australian twins

B Couvy-Duchesne; V O'Callaghan; R Parker; N Mills; K Kirk; Jan Scott; A Vinkhuyzen; Daniel F Hermens; P Lind; T Davenport; J Burns; M Connell; B Zietsch; James Scott; M Wright; S Medland; J McGrath; N Martin; I Hickie; N Gillespie

doi:10.1136/bmjopen-2017-018959

Back

Nineteen and up study (19Up): Understanding pathways to mental health disorders in young Australian twins

Journal article

Open access

Peer reviewed

Nineteen and up study (19Up): Understanding pathways to mental health disorders in young Australian twins

B Couvy-Duchesne, V O'Callaghan, R Parker, N Mills, K Kirk, Jan Scott, A Vinkhuyzen, Daniel F Hermens, P Lind, T Davenport, …

BMJ Open, Vol.8(3), e018959

2018

DOI: https://doi.org/10.1136/bmjopen-2017-018959

Files and links (2)

pdf

PDF - Published Version (Open Access)988.81 kBDownload View

Published VersionPDF - Published Version (Open Access)CC BY-NC V4.0, Open Access

url

https://doi.org/10.1136/bmjopen-2017-018959View

Published Version

Abstract

Clinical Sciences

Public Health and Health Services

Other Medical and Health Sciences

Purpose The Nineteen and Up study (19Up) assessed a range of mental health and behavioural problems and associated risk factors in a genetically informative Australian cohort of young adult twins and their non-twin siblings. As such, 19Up enables detailed investigation of genetic and environmental pathways to mental illness and substance misuse within the Brisbane Longitudinal Twin Sample (BLTS). Participants Twins and their non-twin siblings from Queensland, Australia; mostly from European ancestry. Data were collected between 2009 and 2016 on 2773 participants (age range 18-38, 57.8% female, 372 complete monozygotic pairs, 493 dizygotic pairs, 640 nontwin siblings, 403 singleton twins). Findings to date A structured clinical assessment (Composite International Diagnostic Interview) was used to collect lifetime prevalence of diagnostic statistical manual (4th edition) (DSM-IV) diagnoses of major depressive disorder, (hypo)mania, social anxiety, cannabis use disorder, alcohol use disorder, panic disorder and psychotic symptoms. Here, we further describe the comorbidities and ages of onset for these mental disorders. Notably, twothirds of the sample reported one or more lifetime mental disorder. In addition, the 19Up study assessed general health, drug use, work activity, education level, personality, migraine/headaches, suicidal thoughts, attention deficit hyperactivity disorder (ADHD) symptomatology, sleep- wake patterns, romantic preferences, friendships, familial environment, stress, anorexia and bulimia as well as baldness, acne, asthma, endometriosis, joint flexibility and internet use. The overlap with previous waves of the BLTS means that 84% of the 19Up participants are genotyped, 36% imaged using multimodal MRI and most have been assessed for psychological symptoms at up to four time points. Furthermore, IQ is available for 57%, parental report of ADHD symptomatology for 100% and electroencephalography for 30%. Future plans The 19Up study complements a phenotypically rich, longitudinal collection of environmental and psychological risk factors. Future publications will explore hypotheses related to disease onset and development across the waves of the cohort. A follow-up study at 25+years is ongoing.

Details

Title: Nineteen and up study (19Up): Understanding pathways to mental health disorders in young Australian twins
Authors: B Couvy-Duchesne (Author) - University of Queensland
V O'Callaghan (Author) - University of Queensland
R Parker (Author) - QIMR Berghofer Medical Research Institute
N Mills (Author) - University of Queensland
K Kirk (Author) - QIMR Berghofer Medical Research Institute
Jan Scott (Author) - University of Sydney
A Vinkhuyzen (Author) - University of Queensland
Daniel F Hermens (Author) - University of Sydney
P Lind (Author) - QIMR Berghofer Medical Research Institute
T Davenport (Author) - University of Sydney
J Burns (Author) - University of Melbourne
M Connell (Author) - University of Queensland
B Zietsch (Author) - University of Queensland
James Scott (Author)
M Wright (Author) - University of Queensland
S Medland (Author) - QIMR Berghofer Medical Research Institute
J McGrath (Author) - University of Queensland
N Martin (Author) - QIMR Berghofer Medical Research Institute
I Hickie (Author) - University of Sydney
N Gillespie (Author) - Virginia Commonwealth University, United States
Publication details: BMJ Open, Vol.8(3), e018959
Publisher: B M J Group
Date published: 2018
DOI: 10.1136/bmjopen-2017-018959
ISSN: 2044-6055; 2044-6055
Copyright note: Copyright © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http:// creativecommons. Org/ licenses/ by- nc/ 4. 0/
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99451450602621
Output Type: Journal article

Metrics

12 File views/ downloads

238 Record Views

24 Times Cited - Web of Science

See more details

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Psychiatry

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites