New precursors for the preparation of pH-sensitive, targeting, and loaded non-porous bridged silsesquioxane nanoparticles

C Theron; Albane Birault; M Bernhardt; L M A Ali; Christophe Nguyen; M Gary-Bobo; John R Bartlett; M Wong Chi Man; C Carcel

doi:10.1007/s10971-018-4676-0

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New precursors for the preparation of pH-sensitive, targeting, and loaded non-porous bridged silsesquioxane nanoparticles

Journal article

Peer reviewed

New precursors for the preparation of pH-sensitive, targeting, and loaded non-porous bridged silsesquioxane nanoparticles

C Theron, Albane Birault, M Bernhardt, L M A Ali, Christophe Nguyen, M Gary-Bobo, John R Bartlett, M Wong Chi Man and C Carcel

Journal of Sol-Gel Science and Technology, Vol.89(1), pp.45-55

2019

DOI: https://doi.org/10.1007/s10971-018-4676-0

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Abstract

bridged silsesquioxane nanoparticles

drug delivery

pH-sensitive

one-step drug loading

targeting

Two new tetrasilylated precursors based on a triazine derivative with molecular recognition properties have been synthesized and are shown to efficiently produce pH-sensitive, targeting, and (one-step) loaded non-porous bridged silsesquioxane nanoparticles (nano-BS). This was achieved by the sol-gel hydrolysis-condensation of the precursors in the presence of cyanuric acid (CA) H-bonded through the three complementary faces and mimicking 5-fluorouracil (5-FU) anticancer drug. The complex in the nano-BS is not affected under neutral medium and operates under acidic conditions to deliver the loaded molecule, as demonstrated by FTIR spectroscopic studies. Furthermore, thanks to the presence of the amino function, the nano-BS could be functionalized with targeting or fluorescent systems. Indeed, the grafting of fluorescein isothiocyanate revealed the internalization into cancer cells, confirming that nano-BS are promising materials as carriers to avoid the side effects of anticancer drug due to a controlled and targeted drug delivery.

Details

Title: New precursors for the preparation of pH-sensitive, targeting, and loaded non-porous bridged silsesquioxane nanoparticles
Authors: C Theron (Author) - University of Montpellier, France
Albane Birault (Author) - University of Montpellier, France
M Bernhardt (Author) - University of Montpellier, France
L M A Ali (Author) - Institute of Biomolecules Max Mousseron, France
Christophe Nguyen (Author)
M Gary-Bobo (Author) - Institute of Biomolecules Max Mousseron, France
John R Bartlett (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
M Wong Chi Man (Author) - University of Montpellier, France
C Carcel (Corresponding Author) - University of Montpellier, France
Publication details: Journal of Sol-Gel Science and Technology, Vol.89(1), pp.45-55
Publisher: Springer New York LLC
Date published: 2019
DOI: 10.1007/s10971-018-4676-0
ISSN: 0928-0707; 0928-0707
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99451414202621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Materials Science, Ceramics