Journal article
New Insights on COX-2 in Chronic Inflammation Driving Breast Cancer Growth and Metastasis
Journal of Mammary Gland Biology and Neoplasia, Vol.20, pp.109-119
2015
PMID: 26193871
Abstract
The medicinal use of aspirin stretches back to ancient times, before it was manufactured in its pure form in the late 19th century. Its accepted mechanistic target, cyclooxygenase (COX), was discovered in the 1970s and since this landmark discovery, the therapeutic application of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has increased dramatically. The most significant benefits of NSAIDs are in conditions involving chronic inflammation (CI). Given the recognized role of CI in cancer development, the use of long-term NSAID treatment in the prevention of cancer is an enticing possibility. COX-2 is a key driver of CI, and here we review COX-2 expression as a predictor of survival in various cancer types, including breast. Obesity and post-partum involution are natural inflammatory states that are associated with increased breast cancer risk. We outline the COX-2 mediated mechanisms contributing to the growth of cancers. We dissect the cellular mechanism of epithelial-mesenchymal transition (EMT) and how COX-2 may induce this to facilitate tumor progression. Finally we examine the potential regulation of COX-2 by c-Myb, and the possible interplay between c-Myb/COX-2 in proliferation, and hypoxia inducible factor-1 alpha (HIF1α)/COX-2 in invasive pathways in breast cancer.
Details
- Title
- New Insights on COX-2 in Chronic Inflammation Driving Breast Cancer Growth and Metastasis
- Authors
- Honor Hugo (Author) - St Vincents Institute of Medical ResearchC Saunders (Author) - University of Western AustraliaR G Ramsay (Author) - University of MelbourneE Thompson (Author) - University of Melbourne
- Publication details
- Journal of Mammary Gland Biology and Neoplasia, Vol.20, pp.109-119
- Publisher
- Springer New York LLC
- DOI
- 10.1007/s10911-015-9333-4
- ISSN
- 1573-7039
- PMID
- 26193871
- Organisation Unit
- School of Health and Behavioural Sciences - Legacy; School of Health and Sport Sciences - Legacy; University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99518707302621
- Output Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Web Of Science research areas
- Endocrinology & Metabolism
- Oncology
- Physiology
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Source: InCites