New Biomimetic Directions in Regenerative Ophthalmology

David W Green; Gregory S Watson; Jolanta A Watson; Samuel J K Abraham

doi:10.1002/adhm.201100039

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New Biomimetic Directions in Regenerative Ophthalmology

Journal article

Peer reviewed

New Biomimetic Directions in Regenerative Ophthalmology

David W Green, Gregory S Watson, Jolanta A Watson and Samuel J K Abraham

Advanced Healthcare Materials, Vol.1(2), pp.140-148

2012

DOI: https://doi.org/10.1002/adhm.201100039

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Abstract

Medicinal and Biomolecular Chemistry

Biomedical Engineering

Medical Biotechnology

biomimicry

biomaterials

regenerative medicine

ophthalmology

nanotopography

One of the most complete and permanent ways of treating many causes of visual impairment and blindness is to replace the entire affected tissue with pre-cultured ocular tissues supported and maintained on biomaterial frameworks. One direction towards enhancing ocular tissue regeneration on biomaterials, in the laboratory is by applying biomimicry. Specifically to engineer biomaterials with important functional elements of the native extracellular matrices, such as topography, that support and organise cells into coherent tissues. Further problems in regenerative ophthalmology can be potentially solved through application of biomimicry. They include, more efficient ways of moving and transplanting cultivated tissues into correct therapeutic locations inside the eye and scar-less, non-destructive healing of surgical incisions and wounds, to repair structural integrity of tissues at the ocular surface. Two examples are given to show this potential for redeveloping an ocular epithelium onto a nanostructured insect wing surface and producing an origami membrane modelled on deployable structures in nature. Efforts to harness natural innovation will eventually provide unique designs and structures that cannot for now be made synthetically, for regeneration of clinically acceptable ocular tissues.

Details

Title: New Biomimetic Directions in Regenerative Ophthalmology
Authors: David W Green (Author) - Queensland Eye Institute
Gregory S Watson (Author) - James Cook University
Jolanta A Watson (Author) - James Cook University
Samuel J K Abraham (Author) - Yamanashi University, India
Publication details: Advanced Healthcare Materials, Vol.1(2), pp.140-148
Publisher: Wiley - V C H Verlag GmbH & Co. KGaA
Date published: 2012
DOI: 10.1002/adhm.201100039
ISSN: 2192-2659
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering
Language: English
Record Identifier: 99449349902621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Engineering, Biomedical; Materials Science, Biomaterials; Nanoscience & Nanotechnology

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