Journal article
Neutrophil Antibodies are clinically important
ISBT Science Series, Vol.9(1), pp.253-257
Regional Congress of the International Society of Blood Transfusion (ISBT), 24th (Kuala Lumpur, Malaysia, 01-Dec-2013–04-Dec-2013)
2014
Abstract
Background: Neutrophils or polymorphonuclear neutrophils (PMNs) make up the largest proportion (45 - 70%) of circulating leukocytes and play a pivotal role in innate immunity. Thus, patients with low PMN counts (neutropenia) or defective PMN function are more likely to be overwhelmed by infection. PMN reactive antibodies can cause either allo- or auto-immune neutropenias. In some transfusion-related acute lung injury (TRALI) events, donor derived neutrophil reactive antibodies can cause inappropriate activation of neutrophils leading to collateral damage of the surrounding pulmonary microvasculature with potentially grave clinical consequences. Discussion & Conclusion: Clinical outcomes of TRALI and immune neutropenias demand rapid and precise diagnosis using reliable neutrophil serology. The ISBT Granulocyte Immunobiology Working Party brings together members working in diagnostic laboratories, research and clinical fields to enable strong and productive interactions, innovation and collaboration in granulocyte immunobiology, function and pathology.
Details
- Title
- Neutrophil Antibodies are clinically important
- Authors
- Yoke Lin Fung (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringJ P Tung (Author) - University of QueenslandR M Minchinton (Author) - University of Queensland
- Publication details
- ISBT Science Series, Vol.9(1), pp.253-257
- Conference details
- Regional Congress of the International Society of Blood Transfusion (ISBT), 24th (Kuala Lumpur, Malaysia, 01-Dec-2013–04-Dec-2013)
- Publisher
- Wiley-Blackwell Publishing Ltd.
- Date published
- 2014
- DOI
- 10.1111/voxs.12062
- ISSN
- 1751-2816
- Organisation Unit
- School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99448869902621
- Output Type
- Journal article
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- Domestic collaboration
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- Hematology
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Source: InCites