Neurophysiological correlates of excitement in men with recent-onset psychosis

A Sumich; A Harris; T Whitford; Daniel F Hermens; N Heym; J Anderson; C Bloxsom; F Kibowski; V Kumari

doi:10.24869/psyd.2018.64

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Journal article

Neurophysiological correlates of excitement in men with recent-onset psychosis

A Sumich, A Harris, T Whitford, Daniel F Hermens, N Heym, J Anderson, C Bloxsom, F Kibowski and V Kumari

Psychiatria Danubina, Vol.30(1), pp.64-71

2018

DOI: https://doi.org/10.24869/psyd.2018.64

Appears in Thompson Institute Research Collection

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Abstract

Cognitive Sciences

psychosis

recent-onset

event-related potentials

N200

excitement

drug use

Other Collaborations

Thompson Institute Special Collection

OBJECTIVE: Right frontal function, as indicated by the N200 component of the event-related potential during target detection, has previously been associated with excitement (excitement, impulsivity, hostility, uncooperativeness) in men with a long-term diagnosis of schizophrenia. The current study investigated excitement in relation to N200 in men who had recently experienced their first episode of psychosis. SUBJECTS AND METHODS: Twenty men who had recently suffered their first psychotic episode underwent a clinical interview and auditory oddball task. RESULTS: Multiple linear regression analysis showed that 58% of the variance in the excitement symptom cluster was explained by a positive association with frontal midline N200 amplitude and an inverse association with right frontal N200 amplitude. The latter was not apparent in the initial correlation, suggesting suppression by the midline activity. These associations were not explained by drug use, medication or negative symptoms. However, the correlation between excitement and midline N200 was stronger in drug users, and that between right frontal N200 and excitement was stronger in nonusers. CONCLUSION: Findings support the independent contributions to excitement of mechanisms reflected in midline and right frontal N200 amplitude respectively during the early stages of psychosis.

Details

Title: Neurophysiological correlates of excitement in men with recent-onset psychosis
Authors: A Sumich (Author) - Nottingham Trent University, United Kingdom
A Harris (Author) - University of Sydney
T Whitford (Author) - UNSW
Daniel F Hermens (Author) - University of Sydney
N Heym (Author) - Nottingham Trent University, United Kingdom
J Anderson (Author) - Nottingham Trent University, United Kingdom
C Bloxsom (Author) - Nottingham Trent University, United Kingdom
F Kibowski (Author) - Nottingham Trent University, United Kingdom
V Kumari (Author) - Brunel University London, United Kingdom
Publication details: Psychiatria Danubina, Vol.30(1), pp.64-71
Publisher: Medicinska Naklada Co.
Date published: 2018
DOI: 10.24869/psyd.2018.64
ISSN: 0353-5053
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99450645202621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Psychiatry

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