Journal article
Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistin
Neuron, Vol.63(5), pp.628-642
2009
Abstract
In the mammalian CNS, each neuron typically receives thousands of synaptic inputs from diverse classes of neurons. Synaptic transmission to the postsynaptic neuron relies on localized and transmitter-specific differentiation of the plasma membrane with postsynaptic receptor, scaffolding, and adhesion proteins accumulating in precise apposition to presynaptic sites of transmitter release. We identified protein interactions of the synaptic adhesion molecule neuroligin 2 that drive postsynaptic differentiation at inhibitory synapses. Neuroligin 2 binds the scaffolding protein gephyrin through a conserved cytoplasmic motif and functions as a specific activator of collybistin, thus guiding membrane tethering of the inhibitory postsynaptic scaffold. Complexes of neuroligin 2, gephyrin and collybistin are sufficient for cell-autonomous clustering of inhibitory neurotransmitter receptors. Deletion of neuroligin 2 in mice perturbs GABAergic and glycinergic synaptic transmission and leads to a loss of postsynaptic specializations specifically at perisomatic inhibitory synapses. © 2009 Elsevier Inc. All rights reserved.
Details
- Title
- Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistin
- Authors
- A Poulopoulos (Author) - Max Planck Institute of Experimental Medicine, GermanyG Aramuni (Author) - Georg August University, GermanyG Meyer (Author) - Max Planck Institute of Experimental Medicine, GermanyT Soykan (Author) - Max Planck Institute of Experimental Medicine, GermanyM Hoon (Author) - Max Planck Institute of Experimental Medicine, GermanyT Papadopoulos (Author) - Max Planck Institute of Brain Research, GermanyM Zhang (Author) - Georg August University, GermanyI Paarmann (Author) - Max Planck Institute of Brain Research, GermanyC Fuchs (Author) - University College London, United KingdomK Harvey (Author) - University College London, United KingdomP Jedlicka (Author) - Goethe University, GermanyS W Schwarzacher (Author) - Goethe University, GermanyH Betz (Author) - Max Planck Institute of Brain Research, GermanyRobert J Harvey (Author) - University College London, United KingdomN Brose (Author) - Max Planck Institute of Experimental Medicine, GermanyW Zhang (Author) - Georg August University, GermanyF Varoqueaux (Author) - Max Planck Institute of Experimental Medicine, Germany
- Publication details
- Neuron, Vol.63(5), pp.628-642
- Publisher
- Cell Press
- Date published
- 2009
- DOI
- 10.1016/j.neuron.2009.08.023
- ISSN
- 0896-6273
- Organisation Unit
- School of Health; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; Centre for Bioinnovation; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99450595102621
- Output Type
- Journal article
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