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Neurocognitive functioning predicts suicidal behaviour in young people with affective disorders
Journal article   Peer reviewed

Neurocognitive functioning predicts suicidal behaviour in young people with affective disorders

Catherine M McHugh, Frank Iorfino, Jacob J Crouse, Ashleigh Tickell, Alissa Nichles, Natalia Zmicerevska, Nicholas Ho, Rico S C Lee, Daniel Hermens, Elizabeth M Scott, …
Journal of Affective Disorders, Vol.281, pp.289-296
2021
DOI: https://doi.org/10.1016/j.jad.2020.11.077
PMID: 33341011
Appears in  Thompson Institute Research Collection
url
https://doi.org/10.1016/j.jad.2020.11.077View
Published Version

Abstract

suicidal behaviour neurocognition memory youth and adolescent cognitive flexibility Other Collaborations Thompson Institute Special Collection UniSC Diversity Area - Disability and Inclusion UniSC Diversity Area - Life Stages
Background: Neurocognitive impairment is recognised as a risk factor for suicidal behaviour in adults. The current study aims to determine whether neurocognitive deficits also predict ongoing or emergent suicidal behaviour in young people with affective disorders. Methods: Participants were aged 12-30 years and presented to early intervention youth mental health clinics between 2008 and 2018. In addition to clinical assessment a standardised neurocognitive assessment was conducted at baseline. Clinical data was extracted from subsequent visits using a standardised proforma. Results: Of the 635 participants who met inclusion criteria (mean age 19.6 years, 59% female, average follow up 476 days) 104 (16%) reported suicidal behaviour during care. In 5 of the 10 neurocognitive domains tested (cognitive flexibility, processing speed, working memory, verbal memory and visuospatial memory) those with suicidal behaviour during care were superior to clinical controls. Better general neurocognitive function remained a significant predictor (OR=1.94, 95% CI 1.29- 2.94) of suicidal behaviour in care after controlling for other risk factors. Limitations: The neurocognitive battery used was designed for use with affective and psychotic disorders and may not have detected some deficits more specific to suicidal behaviour. Conclusion: Contrary to expectations, better neurocognitive functioning predicts suicidal behaviour during care in young people with affective disorders. While other populations with suicidal behaviour, such as adults with affective disorders or young people with psychotic disorders, tend to experience neurocognitive deficits which may limit their capacity to engage in some interventions, this does not appear to be the case for young people with affective disorders.

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Clinical Neurology
Psychiatry

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