Journal article
Neurochemical changes underpinning the development of adjunct therapies in recovery after stroke: A role for GABA?
Journal of Cerebral Blood Flow and Metabolism, Vol.38(9), pp.1564-1583
2018
PMCID: PMC6125966
PMID: 28929902
Abstract
Stroke is a leading cause of long-term disability, with around three-quarters of stroke survivors experiencing motor problems. Intensive physiotherapy is currently the most effective treatment for post-stroke motor deficits, but much recent research has been targeted at increasing the effects of the intervention by pairing it with a wide variety of adjunct therapies, all of which aim to increase cortical plasticity, and thereby hope to maximize functional outcome. Here, we review the literature describing neurochemical changes underlying plasticity induction following stroke. We discuss methods of assessing neurochemicals in humans, and how these measurements change post-stroke. Motor learning in healthy individuals has been suggested as a model for stroke plasticity, and we discuss the support for this model, and what evidence it provides for neurochemical changes. One converging hypothesis from animal, healthy and stroke studies is the importance of the regulation of the inhibitory neurotransmitter GABA for the induction of cortical plasticity. We discuss the evidence supporting this hypothesis, before finally summarizing the literature surrounding the use of adjunct therapies such as non-invasive brain stimulation and SSRIs in post-stroke motor recovery, both of which have been show to influence the GABAergic system.
Details
- Title
- Neurochemical changes underpinning the development of adjunct therapies in recovery after stroke: A role for GABA?
- Authors
- Ainslie Johnstone (Author) - University of OxfordJacob M Levenstein (Author) - University of OxfordEmily L Hinson (Author) - University of OxfordCharlotte J Stagg (Author) - University of Oxford
- Publication details
- Journal of Cerebral Blood Flow and Metabolism, Vol.38(9), pp.1564-1583
- Publisher
- Sage Publications Ltd.
- DOI
- 10.1177/0271678X17727670
- ISSN
- 1559-7016
- PMID
- 28929902; PMC6125966
- Organisation Unit
- University of the Sunshine Coast, Queensland; Thompson Institute
- Language
- English
- Record Identifier
- 99639278702621
- Output Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Endocrinology & Metabolism
- Hematology
- Neurosciences
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