Neurobiology Youth Follow-up Study: protocol to establish a longitudinal and prospective research database using multimodal assessments for current and past mental health treatment-seeking young people within an early intervention service

Alissa Nichles; Natalia Zmicerevska; Yun Ju Christine Song; Chloe Wilson; Catherine McHugh; Blake Hamilton; Jacob Crouse; Cathrin Rohleder; Joanne Sarah Carpenter; Nicholas Ho; Daniel F Hermens; Naomi Wray; Jan Scott; Kathleen R Merikangas; F Markus Leweke; Dagmar Koethe; Frank Iorfino; Sharon L Naismith; Adam J Guastella; Ian B Hickie; Elizabeth M Scott

doi:10.1136/bmjopen-2020-044731

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Neurobiology Youth Follow-up Study: protocol to establish a longitudinal and prospective research database using multimodal assessments for current and past mental health treatment-seeking young people within an early intervention service

Journal article

Open access

Peer reviewed

Neurobiology Youth Follow-up Study: protocol to establish a longitudinal and prospective research database using multimodal assessments for current and past mental health treatment-seeking young people within an early intervention service

Alissa Nichles, Natalia Zmicerevska, Yun Ju Christine Song, Chloe Wilson, Catherine McHugh, Blake Hamilton, Jacob Crouse, Cathrin Rohleder, Joanne Sarah Carpenter, Nicholas Ho, …

BMJ Open, Vol.11(6), pp.1-8

2021

DOI: https://doi.org/10.1136/bmjopen-2020-044731

PMID: 34145010

Appears in Thompson Institute Research Collection

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Abstract

Neurobiology

Psychosis

Neurosciences

Early intervention

Sleep

Circadian rhythm

Metabolism

Neuropsychology

Mental health care

Mental disorders

Other Collaborations

Thompson Institute Special Collection

UniSC Diversity Area - Disability and Inclusion

UniSC Diversity Area - Life Stages

Introduction: Approximately 75% of major mental illness occurs before the age of 25 years. Despite this, our capacity to provide effective, early and personalised interventions is limited by insufficient evidence for characterising early-stage, and less specific, presentations of major mental disorders in youth populations. This article describes the protocol for setting up a large-scale database that will collect longitudinal, prospective data that incorporate clinical, social and occupational function, neuropsychological, circadian, metabolic, family history and genetic metrics. By collecting data in a research-purposed, standardised manner, the ‘Neurobiology Youth Follow-up Study’ should improve identification, characterisation and profiling of youth attending mental healthcare, to better inform diagnosis and treatment at critical time points. The overall goal is enhanced long-term clinical and functional outcomes. Methods and analysis: This longitudinal clinical cohort study will invite participation from youth (12–30 years) who seek help for mental health-related issues at an early intervention service (headspace Camperdown) and linked services. Participants will be prospectively tracked over 3 years with a series of standardised multimodal assessments at baseline, 6, 12, 24 and 36 months. Evaluations will include: (1) clinician-administered and self-report assessments determining clinical stage, pathophysiological pathways to illness, diagnosis, symptomatology, social and occupational function; (2) neuropsychological profile; (3) sleep–wake patterns and circadian rhythms; (4) metabolic markers and (5) genetics. These data will be used to: (1) model the impact of demographic, phenomenological and treatment variables, on clinical and functional outcomes; (2) map neurobiological profiles and changes onto a transdiagnostic clinical stage and pathophysiological mechanisms framework. Ethics and dissemination: This study protocol has been approved by the Human Research Ethics Committee of the Sydney Local Health District (2020/ETH01272, protocol V.1.3, 14 October 2020). Research findings will be disseminated through peer-reviewed journals and presentations at scientific conferences and to user and advocacy groups. Participant data will be de-identified.

Details

Title: Neurobiology Youth Follow-up Study: protocol to establish a longitudinal and prospective research database using multimodal assessments for current and past mental health treatment-seeking young people within an early intervention service
Authors: Alissa Nichles (Author) - The University of Sydney
Natalia Zmicerevska (Author) - The University of Sydney
Yun Ju Christine Song (Author) - The University of Sydney
Chloe Wilson (Author) - The University of Sydney
Catherine McHugh (Author) - The University of Sydney
Blake Hamilton (Author) - The University of Sydney
Jacob Crouse (Author) - The University of Sydney
Cathrin Rohleder (Author) - The University of Sydney
Joanne Sarah Carpenter (Author) - The University of Sydney
Nicholas Ho (Author) - The University of Sydney
Daniel F Hermens (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Naomi Wray (Author) - The University of Queensland
Jan Scott (Author) - University of Newcastle Australia
Kathleen R Merikangas (Author) - National Institute of Mental Health
F Markus Leweke (Author) - The University of Sydney
Dagmar Koethe (Author) - The University of Sydney
Frank Iorfino (Author) - The University of Sydney
Sharon L Naismith (Author) - The University of Sydney
Adam J Guastella (Author) - The University of Sydney
Ian B Hickie (Author) - The University of Sydney
Elizabeth M Scott (Author) - The University of Notre Dame - Sydney Campus
Publication details: BMJ Open, Vol.11(6), pp.1-8
Publisher: BMJ Group
Date published: 2021
DOI: 10.1136/bmjopen-2020-044731
ISSN: 2044-6055
PMID: 34145010
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99548407602621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Psychiatry

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