Files and links (2)
NeuroExercise - The Effect of a 12-Month Exercise Intervention on Cognition in Mild Cognitive Impairment—A Multicenter Randomized Controlled Trial1.70 MB
Published VersionCC BY V4.0, Open Access
Journal article
NeuroExercise: The Effect of a 12-Month Exercise Intervention on Cognition in Mild Cognitive Impairment—A Multicenter Randomized Controlled Trial
Frontiers in Aging Neuroscience, Vol.12, pp.1-12
2021
PMID: 33519425
Abstract
Exercise intervention studies in mild cognitive impairment (MCI), a prodromal stage of Alzheimer's disease (AD), have demonstrated inconsistent yet promising results. Addressing the limitations of previous studies, this trial investigated the effects of a 12-month structured exercise program on the progression of MCI. The NeuroExercise study is a multicenter randomized controlled trial across three European countries (Ireland, Netherlands, Germany). Hundred and eighty-three individuals with amnestic MCI were included and were randomized to a 12-month exercise intervention (3 units of 45 min) of either aerobic exercise (AE; n = 60), stretching and toning exercise (ST; n = 65) or to a non-exercise control group (CG; n = 58). The primary outcome, cognitive performance, was determined by an extensive neuropsychological test battery. For the primary complete case (CC) analyses, between-group differences were analyzed with analysis of covariance under two conditions: (1) the exercise group (EG = combined AE and ST groups) compared to the CG and (2) AE compared to ST. Primary analysis of the full cohort (n = 166, 71.5 years; 51.8% females) revealed no between-group differences in composite cognitive score [mean difference (95% CI)], 0.12 [(−0.03, 0.27), p = 0.13] or in any cognitive domain or quality of life. VO2 peak was significantly higher in the EG compared to the CG after 12 months [−1.76 (−3.39, −0.10), p = 0.04]. Comparing the two intervention groups revealed a higher VO2peak level in the aerobic exercise compared to the stretching and toning group, but no differences for the other outcomes. A 12-month exercise intervention did not change cognitive performance in individuals with amnestic MCI in comparison to a non-exercise CG. An intervention effect on physical fitness was found, which may be an important moderator for long term disease progression and warrants long-term follow-up investigations.
Details
- Title
- NeuroExercise: The Effect of a 12-Month Exercise Intervention on Cognition in Mild Cognitive Impairment—A Multicenter Randomized Controlled Trial
- Authors
- Tim Stuckenschneider (Author) - University of the Sunshine Coast, Queensland, School of Health and Sport Sciences - LegacyMarit L Sanders (Author) - Radboud University Medical CenterKate E Devenney (Author) - Trinity College DublinJustine A Aaronson (Author) - Trinity College DublinVera Abeln (Author) - German Sport University CologneJurgen A H R Claassen (Author) - Radboud University Medical CenterEmer Guinan (Author) - Trinity College DublinBrian Lawlor (Author) - Trinity College DublinRomain Meeusen (Author) - Vrije Universiteit BrusselChristian Montag (Author) - Universität UlmMarcel G M Olde Rikkert (Author) - Radboud University Medical CenterM Cristina Polidori (Author) - University of CologneMartin Reuter (Author) - University of BonnRalf-Joachim Schulz (Author) - University of CologneTobias Vogt (Author) - German Sport University CologneBernd Weber (Author) - Trinity College DublinRoy P C Kessels (Author) - Radboud University Medical CenterStefan Schneider (Author) - University of the Sunshine Coast, Queensland, School of Health and Sport Sciences - LegacyNeuroExercise Study Group (Author)
- Publication details
- Frontiers in Aging Neuroscience, Vol.12, pp.1-12
- Publisher
- Frontiers Research Foundation
- Date published
- 2021
- DOI
- 10.3389/fnagi.2020.621947
- ISSN
- 1663-4365
- PMID
- 33519425
- Copyright note
- © 2021 Stuckenschneider, Sanders, Devenney, Aaronson, Abeln, Claassen, Guinan, Lawlor, Meeusen, Montag, Olde Rikkert, Polidori, Reuter, Schulz, Vogt, Weber, Kessels and Schneider. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Organisation Unit
- University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy
- Language
- English
- Record Identifier
- 99508608102621
- Output Type
- Journal article
Metrics
15 File views/ downloads
45 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Geriatrics & Gerontology
- Neurosciences
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites