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Food Science Nutrition - 2023 - Cao - Naringenin prevents non‐alcoholic steatohepatitis by modulating the host metabolome35.54 MB
Published VersionCC BY V4.0, Open Access
Journal article
Naringenin prevents non‐alcoholic steatohepatitis by modulating the host metabolome and intestinal microbiome in MCD diet‐fed mice
Food Science & Nutrition, Vol.11(12), pp.7826-7840
2023
PMID: 38107095
Abstract
Non-alcoholic steatohepatitis (NASH) is a severe inflammatory phase of the non-alcoholic fatty liver disease (NAFLD) spectrum and can progress to advanced stages of NAFLD if left untreated. This study uses multi-omics data to elucidate the underlying mechanism of naringenin's reported benefit in alleviating (NASH). Male mice were fed a NASH-inducing (methionine-choline-deficient) MCD diet with or without naringenin supplementation for 6 weeks. Naringenin prevented NASH-induced histopathological liver damage and reversed the abnormal levels of hepatic triglyceride (TG)/total cholesterol (TC), serum TG/TC, serum alanine aminotransferase/aspartate transaminase, and hepatic malondialdehyde and glutathione. Importantly, naringenin intervention significantly modulated the relative abundance of gut microbiota and the host metabolomic profile. We detected more than 700 metabolites in the serum and found that the gut genus levels of Anaeroplasma and the [Eubacterium] nodatum group were closely associated with xanthine, 2-picoline, and securinine, respectively. Tuzzerella alterations showed the highest number of associations with host endogenous metabolites such as FAHFA (8:0/10:0), FFA (20:2), carnitine C8:1, tridecanedioic acid, securinine, acetylvaline, DL-O-tyrosine, and Phe-Asn. This study indicates that the interplay between host serum metabolites and gut microbiota may contribute to the therapeutic effect of naringenin against NASH.
Details
- Title
- Naringenin prevents non‐alcoholic steatohepatitis by modulating the host metabolome and intestinal microbiome in MCD diet‐fed mice
- Authors
- Peng Cao (Corresponding Author) - Huazhong University of Science and TechnologyMing Yue - Hubei University of MedicineYuanlei Cheng - Hubei University of MedicineMitchell A Sullivan - The University of QueenslandWen Chen - Huazhong University of Science and TechnologyHuifan Yu - Hubei University of MedicineFei Li - Hubei University of MedicineSanlan Wu - Huazhong University of Science and TechnologyYongning Lv - Huazhong University of Science and TechnologyXuejia Zhai (Corresponding Author) - Huazhong University of Science and TechnologyYu Zhang (Corresponding Author) - Huazhong University of Science and Technology
- Publication details
- Food Science & Nutrition, Vol.11(12), pp.7826-7840
- Publisher
- John Wiley & Sons Ltd.
- Date published
- 2023
- DOI
- 10.1002/fsn3.3700
- ISSN
- 2048-7177
- PMID
- 38107095
- Copyright note
- This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2023 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC.
- Data Availability
- Data are available by contacting the corresponding author (Dr. Peng Cao).
- Grant note
- National Natural Science Foundation of China, Grant/Award Number: 81903901
- Organisation Unit
- School of Health - Biomedicine
- Language
- English
- Record Identifier
- 991035092802621
- Output Type
- Journal article
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