Nanotechnology in the management of cervical cancer

Jiezhong Chen; Wenyi Gu; Lei Yang; Chen Chen; Renfu Shao; Kewei Xu; Zhi Ping Xu

doi:10.1002/rmv.1825

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Nanotechnology in the management of cervical cancer

Journal article

Peer reviewed

Nanotechnology in the management of cervical cancer

Jiezhong Chen, Wenyi Gu, Lei Yang, Chen Chen, Renfu Shao, Kewei Xu and Zhi Ping Xu

Reviews in Medical Virology, Vol.25(Supplement 1), pp.72-83

2015

DOI: https://doi.org/10.1002/rmv.1825

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Abstract

nanotechnology

cervical cancer

human papillomaviruses (HPV)

treatment

diagnosis

Cervical cancer is a major disease with high mortality. All cervical cancers are caused by infection with human papillomaviruses (HPV). Although preventive vaccines for cervical cancer are successful, treatment of cervical cancer is far less satisfactory because of multidrug resistance and side effects. In this review, we summarize the recent application of nanotechnology to the diagnosis and treatment of cervical cancer as well as the development of HPV vaccines. Early detection of cervical cancer enables tumours to be efficiently removed by surgical procedures, leading to increased survival rate. The current method of detecting cervical cancer by Pap smear can only achieve 50% sensitivity, whereas nanotechnology has been used to detect HPVs with greatly improved sensitivity. In cervical cancer treatment, nanotechnology has been used for the delivery of anticancer drugs to increase treatment efficacy and decrease side effects. Nanodelivery of HPV preventive and therapeutic vaccines has also been investigated to increase vaccine efficacy. Overall, these developments suggest that nanoparticle-based vaccine may become the most effective way to prevent and treat cervical cancer, assisted or combined with some other nanotechnology-based therapy. Copyright © 2015 John Wiley & Sons, Ltd.

Details

Title: Nanotechnology in the management of cervical cancer
Authors: Jiezhong Chen (Author) - University of Queensland
Wenyi Gu (Author) - University of Queensland
Lei Yang (Author) - Hangzhou Normal University, China
Chen Chen (Author) - University of Queensland
Renfu Shao (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Kewei Xu (Author) - University of Queensland
Zhi Ping Xu (Author) - University of Queensland
Publication details: Reviews in Medical Virology, Vol.25(Supplement 1), pp.72-83
Publisher: John Wiley & Sons Ltd.
Date published: 2015
DOI: 10.1002/rmv.1825
ISSN: 1052-9276
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99450183402621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Virology

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