Nanoscale study of cartilage surfaces using atomic force microscopy

Meiling Wang; Zhongxiao Peng; Jolanta A Watson; Gregory S Watson; Ling Yin

doi:10.1177/0954411912460482

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Nanoscale study of cartilage surfaces using atomic force microscopy

Journal article

Peer reviewed

Nanoscale study of cartilage surfaces using atomic force microscopy

Meiling Wang, Zhongxiao Peng, Jolanta A Watson, Gregory S Watson and Ling Yin

Institution of Mechanical Engineers. Proceedings. Part H: Journal of Engineering in Medicine, Vol.226(11), pp.899-910

2012

DOI: https://doi.org/10.1177/0954411912460482

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Abstract

Biomedical Engineering

Mechanical Engineering

effective indentation modulus

cartilage surface

surface morphology

wear

atomic force microscopy

Articulating cartilage wear plays an important role in cartilage degeneration and osteoarthritis (OA) progression. This study investigated the changes of mechanical properties and surface roughness of sheep cartilages with wear progression at a nanometre scale. Young sheep's rear legs were subjected to a series of wear tests to generate worn cartilage samples to simulate the OA progression. Atomic force microscopy (AFM) was used to determine the effective indentation modulus and to measure the surface morphology of moist cartilage surfaces. The study has found that the mean effective indentation modulus values of worn cartilages were lower than that of healthy cartilage as the control sample. A medium-to-strong correlation between the effective indentation modulus values and the OA grades has been found. The relation between surface topography and effective indentation modulus values of the cartilage surfaces with OA progression was weakly correlated. The method established in this study can be implemented to investigate the effective indentation modulus values of clinical osteoarthritic cartilages and to assist in the understanding and assessment of OA.

Details

Title: Nanoscale study of cartilage surfaces using atomic force microscopy
Authors: Meiling Wang (Author) - University of New South Wales
Zhongxiao Peng (Author) - University of New South Wales
Jolanta A Watson (Author) - James Cook University
Gregory S Watson (Author) - James Cook University
Ling Yin (Author) - James Cook University
Publication details: Institution of Mechanical Engineers. Proceedings. Part H: Journal of Engineering in Medicine, Vol.226(11), pp.899-910
Publisher: Sage Publications Ltd.
Date published: 2012
DOI: 10.1177/0954411912460482
ISSN: 0954-4119
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering
Language: English
Record Identifier: 99448727802621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Engineering, Biomedical

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