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NOS1AP is associated with increased severity of PTSD and depression in untreated combat veterans157.40 kB
Accepted VersionCC BY-NC-ND V4.0, Open Access
Journal article
NOS1AP is associated with increased severity of PTSD and depression in untreated combat veterans
Journal of Affective Disorders, Vol.147(1-3), pp.87-93
2013
PMID: 23146198
Abstract
Background:
Posttraumatic stress disorder (PTSD) and depressive disorder are over represented in combat veterans. Veterans with both disorders have an increased risk of suicide. The nitric oxide synthase 1 adaptor protein (NOS1AP) gene, which modulates stress-evoked N-methyl-d-aspartate (NMDA) activity, was investigated in combat veterans.
Methods:
A comprehensive genetic analysis of NOS1AP and its association with PTSD was investigated in Vietnam combat veterans with PTSD (n=121) and a group of healthy control individuals (n=237). PTSD patients were assessed for symptom severity and level of depression using the Mississippi Scale for Combat-Related PTSD and the Beck Depression Inventory-II (BDI).
Results:
The G allele of NOS1AP SNP rs386231 was significantly associated with PTSD (p=0.002). Analysis of variance revealed significant differences in BDI-II and Mississippi scores between genotypes for rs386231 with the GG genotype associated with increased severity of depression (p=0.002 F=6.839) and higher Mississippi Scale for Combat-Related PTSD scores (p=0.033). Haplotype analysis revealed that the C/G haplotype (rs451275/rs386231) was significantly associated with PTSD (p=0.001).
Limitations:
The sample sizes in our study were not sufficient to detect SNP associations with very small effects. In addition the study was limited by its cross sectional design.
Conclusions:
This is the first study reporting that a variant of the NOS1AP gene is associated with PTSD. Our data also suggest that a genetic variant in NOS1AP may increase the susceptibility to severe depression in patients with PTSD and increased risk for suicide.
Details
- Title
- NOS1AP is associated with increased severity of PTSD and depression in untreated combat veterans
- Authors
- Bruce R Lawford (Author) - Queensland University of TechnologyCharles P Morris (Author) - Queensland University of TechnologyChristopher D Swagell (Author) - Queensland University of TechnologyIan P Hughes (Author) - Queensland University of TechnologyRoss Young (Author) - Queensland University of TechnologyJoanne Voisey (Author) - Queensland University of Technology
- Publication details
- Journal of Affective Disorders, Vol.147(1-3), pp.87-93
- Publisher
- Elsevier BV
- Date published
- 2013
- DOI
- 10.1016/j.jad.2012.10.013
- ISSN
- 1573-2517; 0165-0327
- PMID
- 23146198
- Copyright note
- Copyright © 2013. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
- Organisation Unit
- University of the Sunshine Coast, Queensland; Office of the Deputy Vice-Chancellor (Research and Innovation)
- Language
- English
- Record Identifier
- 99551706102621
- Output Type
- Journal article
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- International collaboration
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- Clinical Neurology
- Psychiatry
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