NMR fingerprints, an integrated approach to uncover the unique components of the drug-like natural product metabolome of termite gut-associated Streptomyces species

C A Romero; T Grkovic; J Han; L Zhang; John R J French; D Ipek Kurtboke; R J Quinn

doi:10.1039/C5RA17553D

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NMR fingerprints, an integrated approach to uncover the unique components of the drug-like natural product metabolome of termite gut-associated Streptomyces species

Journal article

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NMR fingerprints, an integrated approach to uncover the unique components of the drug-like natural product metabolome of termite gut-associated Streptomyces species

C A Romero, T Grkovic, J Han, L Zhang, John R J French, D Ipek Kurtboke and R J Quinn

RSC Advances, Vol.5, pp.104524-104534

2015

DOI: https://doi.org/10.1039/C5RA17553D

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Abstract

Chemical Sciences

A new NMR-based method to access to the unique components of the drug-like natural product metabolome of termite-gut associated actinomycetes has been developed. This approach was used to accelerate the identification of lead-like enhanced fractions containing small molecules with unique spectral patterns. The effectiveness of the approach was demonstrated by the isolation and identification of six new natural products, namely, actinoglycosidines A (1) and B (2), actinopolymorphol D (3), niveamycin A (7), B (8) and C (9).

Details

Title: NMR fingerprints, an integrated approach to uncover the unique components of the drug-like natural product metabolome of termite gut-associated Streptomyces species
Authors: C A Romero (Author) - Griffith University
T Grkovic (Author) - Griffith University
J Han (Author) - Chinese Academy of Science, China
L Zhang (Author) - Chinese Academy of Science, China
John R J French (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
D Ipek Kurtboke (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
R J Quinn (Author) - Griffith University
Publication details: RSC Advances, Vol.5, pp.104524-104534
Publisher: Royal Society of Chemistry (R S C) Publications
Date published: 2015
DOI: 10.1039/C5RA17553D
ISSN: 2046-2069
Copyright note: Copyright © 2015 The Royal Society of Chemistry. The author accepted version is reproduced here in accordance with the copyright policy of the publisher. Restrictions on further re-use and distribution apply.
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; GeneCology Research Centre - Legacy; School of Science, Technology and Engineering
Language: English
Record Identifier: 99449311102621
Output Type: Journal article

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