Mutations in the MYB intron I regulatory sequence increase transcription in colon cancers

Honor Hugo; Alina Cures; Nirosha Suraweera; Yvette Drabsch; Damian Purcell; Theo Mantamadiotis; Wayne Phillips; Alex Dobrovic; Gabriella Zupi; Thomas J Gonda; Barry Iacopetta; Robert G Ramsay

doi:10.1002/gcc.20378

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Mutations in the MYB intron I regulatory sequence increase transcription in colon cancers

Journal article

Peer reviewed

Mutations in the MYB intron I regulatory sequence increase transcription in colon cancers

Honor Hugo, Alina Cures, Nirosha Suraweera, Yvette Drabsch, Damian Purcell, Theo Mantamadiotis, Wayne Phillips, Alex Dobrovic, Gabriella Zupi, Thomas J Gonda, …

Genes, Chromosomes & Cancer, Vol.45(12), pp.1143-1154

2006

DOI: https://doi.org/10.1002/gcc.20378

PMID: 16977606

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Abstract

Although MYB overexpression in colorectal cancer (CRC) is known to be a prognostic indicator for poor survival, the basis for this overexpression is unclear. Among multiple levels of MYB regulation, the most dynamic is the control of transcriptional elongation by sequences within intron 1. The authors have proposed that this regulatory sequence is transcribed into an RNA stem-loop and 19-residue polyuridine tract, and is subject to mutation in CRC. When this region was examined in colorectal and breast carcinoma cell lines and tissues, the authors found frequent mutations only in CRC. It was determined that these mutations allowed increased transcription compared with the wild type sequence. These data suggest that this MYB regulatory region within intron 1 is subject to mutations in CRC but not breast cancer, perhaps consistent with the mutagenic insult that occurs within the colon and not mammary tissue. In CRC, these mutations may contribute to MYB overexpression, highlighting the importance of noncoding sequences in the regulation of key cancer genes.

Details

Title: Mutations in the MYB intron I regulatory sequence increase transcription in colon cancers
Authors: Honor Hugo (Author) - University of Melbourne
Alina Cures (Author) - St Mark's Hospital
Nirosha Suraweera (Author) - University of Queensland
Yvette Drabsch (Author) - University of Melbourne
Damian Purcell (Author) - Regina Elena Institute (Rome, Italy)
Theo Mantamadiotis (Author) - University of Melbourne
Wayne Phillips (Author) - University of Melbourne
Alex Dobrovic (Author) - University of Melbourne
Gabriella Zupi (Author) - University of Western Australia
Thomas J Gonda (Author) - University of Queensland
Barry Iacopetta (Author) - University of Western Australia
Robert G Ramsay (Author) - University of Melbourne
Publication details: Genes, Chromosomes & Cancer, Vol.45(12), pp.1143-1154
Publisher: John Wiley & Sons, Inc.
DOI: 10.1002/gcc.20378
ISSN: 1098-2264
PMID: 16977606
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99518707802621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Genetics & Heredity; Oncology

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