Murine neonatal melanocytes exhibit a heightened proliferative response to ultraviolet radiation and migrate to the epidermal basal layer

G J Walker; Michael G Kimlin; E Hacker; S Ravishankar; H K Muller; F Beermann; N K Hayward

doi:10.1038/jid.2008.210

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Murine neonatal melanocytes exhibit a heightened proliferative response to ultraviolet radiation and migrate to the epidermal basal layer

Journal article

Peer reviewed

Murine neonatal melanocytes exhibit a heightened proliferative response to ultraviolet radiation and migrate to the epidermal basal layer

G J Walker, Michael G Kimlin, E Hacker, S Ravishankar, H K Muller, F Beermann and N K Hayward

Journal of Investigative Dermatology, Vol.129(1), pp.184-193

2009

DOI: https://doi.org/10.1038/jid.2008.210

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Abstract

cell proliferation

epidermis

melanoma

radiation exposure

ultraviolet radiation

Melanocytes respond to UVR not only by producing melanin, but also by proliferating. This is essentially a protective response. We have studied the melanocyte proliferative response after a single UVR exposure to neonatal mice. At 3 days post-UVR in wild-type neonates we observed a marked melanocyte activation not seen in adults. Melanocytes migrated to the epidermal basal layer, their numbers peaking at 3-5 days after UVR then diminishing. They appeared to emanate from the hair follicle, migrating to the epidermis via the outer root sheath. In melanoma-prone mice with melanocyte-specific overexpression of Hras(G12V), basal layer melanocytes were increased in size and dendricity compared to UVR-treated wild-type mice. Melanocytes in mice carrying a pRb pathway cell-cycle defect (oncogenic Cdk4(R24C)) did not show an enhanced response to UVR such as those carrying Hras(G12V). The exquisite sensitivity to UVR-induced proliferation and migration that characterizes neonatal mouse melanocytes may partly explain the utility of this form of exposure for inducing melanoma in mice that carry oncogenic mutations.

Details

Title: Murine neonatal melanocytes exhibit a heightened proliferative response to ultraviolet radiation and migrate to the epidermal basal layer
Authors: G J Walker (Author) - Queensland Institute of Medical Research
Michael G Kimlin (Author) - Queensland University of Technology
E Hacker (Author) - Queensland Institute of Medical Research
S Ravishankar (Author) - Queensland Institute of Medical Research
H K Muller (Author) - University of Tasmania
F Beermann (Author) - Swiss Institute for Experimental Cancer Research, Switzerland
N K Hayward (Author) - Queensland Institute of Medical Research
Publication details: Journal of Investigative Dermatology, Vol.129(1), pp.184-193
Publisher: Nature Publishing Group
Date published: 2009
DOI: 10.1038/jid.2008.210
ISSN: 0022-202X
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy
Language: English
Record Identifier: 99450054202621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Dermatology

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